#Efficacy

Jean Marc Benoit MD

JeanmarcBenoit

Lockdown as experimental therapy for population health. A research protocolIn order to evaluate a therapy in medical trials, it is ideally subjected to randomized, placebo ("sham") controlled trials. Often, medicine

Kaspar Rufibach

numbersman77

1) Why do we run group-sequential trials in drug development? 2) How does the effect we power at relate to the effect(s) needed to stop?3) Is stopping such a trial

F. Perry Wilson, MD MSCE

fperrywilson

Seeing an interesting question coming up here - should we just give as many people as possible dose 1 of the Pfizer vaccine and not worry so much about dose

Michael Donnelly

donnellymjd

The latest preprint analysis of the B117 variant has this variant becoming dominant in the US in March. That's similar to my forecasts, though I don't think this analysis has

Lyman Stone 石來民

lymanstoneky

the highest credible estimate of COVID's base R value in the United States (i.e. pre-March 1) is 3, which suggests you only need 66% immunity to keep R durably below

Andrew Longhurst

a_longhurst

1) Initial thoughts on int'l travel measures. Better late than never. Will discourage travel. But why not keep it simple, align with #covidzero best practices: only essential travel into Cda,

Walid Gellad, MD MPH

walidgellad

Listening to @DukeMargolis seminar on Covid vaccine. Peter Marks mentions that they expect a median of 2 month follow-up of safety for individuals in trials at time of EUA. He

Trevor Bedford

trvrb

Today's announcement of ~95% efficacy in the @moderna_tx #COVID19 vaccine trial is amazing, auspicious news. 1/8https://www.statnews.com/2020/11/16/modernas-covid-19-vaccine-is-strongly-effective-early-look-at-data-show/ This coupled wi

Prof. Akiko Iwasaki

VirusesImmunity

How well do various vaccines reduce severe COVID disease & death? Awesome @YaleMed students, @dariusdariusdar, @ChaneyKalinich, @Larson_HaleighT & Caroline Valdez put together summary tables from vaccine trials. Remarkable ability o

Yanga Mdleleni👩🏽‍🔬🧘🏾‍♀️🇿🇦

Yanga_md

There is clearly a lot of circulating misinformation leading to mistrust and vaccine hesitancy regarding vaccines for South Africa. Vaccines DO NOT spread infections. Instead, they are designed to protect

Joe Biden

JoeBiden

A safe and effective COVID-19 vaccine could save countless lives. We need one as soon as possible.But while I see a vaccine as a product of science, President Trump sees

Dr. Purvi Parwani

purviparwani

Doing this as PSA!Those who are worried about side effects of the vaccine- here is the @NEJM paper on #Pfizer #Covid vaccine! https://www.nejm.org/doi/10.1056/NEJMoa2034577@DBelardoMD @mirvatalasnag @onco_cardiology @AChoiHeart @SaynaNorouz

Giorgio Gilestro

giorgiogilestro

Living in the UK, I've heard lots of triumphalistic announcements regarding AZ approval on the radio so I think it's wise to offer a complete perspective of what happened. Here's

Shane Crotty

profshanecrotty

1/ The second COVID-19 vaccine trial results have been released. 94.5% estimated efficacy! Outstanding news. These are Moderna vaccine results, independent of the Pfizer results a week ago. So there

Dr Nicole E Basta

IDEpiPhD

As you consider the #COVID19 #vaccine debates about 1 vs 2 doses, timing of 2nd dose & dosing w/ 2 diff vaccines, keep in mind there is no "right" answer

Roland Baker

RolandBakerIII

Dr. Flavinkins has a point that I can't falsify [see thread]. SARS-Cov-2 passaged through BALB/c mice induced adoption via a mutation: N501K. This same lineage appears in the UK with

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