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How well do various vaccines reduce severe COVID disease & death? Awesome @YaleMed students, @dariusdariusdar, @ChaneyKalinich, @Larson_HaleighT & Caroline Valdez put together summary tables from vaccine trials. Remarkable ability of vaccines to 
severe/lethal COVID! 
(1/n)
severe/lethal COVID! (1/n)
The phase 3 Pfizer BioNTech two-shot mRNA vaccine trial data. All the tables here and below indicate the # COVID-related death in the vaccinated as the right-most column (which is ZERO). (2/n)
https://www.nejm.org/doi/full/10.1056/NEJMoa2034577#.YCAZi3KidkU.twitter
https://www.nejm.org/doi/full/10.1056/NEJMoa2034577#.YCAZi3KidkU.twitter
The phase 3 Moderna two-shot mRNA vaccine COVE trial. (3/n)
https://www.nejm.org/doi/full/10.1056/NEJMoa2035389#.YCAaBNSBGIw.twitter
https://www.nejm.org/doi/full/10.1056/NEJMoa2035389#.YCAaBNSBGIw.twitter
The phase 3 trial of AstraZeneca Oxford Chimp Adeno ChAdOx1 vaccine. Two-shots - Standard doses 1 and 2 or Low dose 1 + Standard dose 2. (4/n)
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3777268
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3777268
Novavax recombinant spike protein + Matrix M adjuvant two-shot vaccine efficacy data. (5/n)
https://ir.novavax.com/news-releases/news-release-details/novavax-announces-initiation-prevent-19-pivotal-phase-3-efficacy
For more, see https://twitter.com/kakape/status/1354911677276422145
https://ir.novavax.com/news-releases/news-release-details/novavax-announces-initiation-prevent-19-pivotal-phase-3-efficacy
For more, see https://twitter.com/kakape/status/1354911677276422145
Johnson & Johnson single-shot Janssen Ad26.COV2.S Phase 3 ENSEMBLE trial efficacy data. (6/n)
https://www.jnj.com/johnson-johnson-announces-single-shot-janssen-covid-19-vaccine-candidate-met-primary-endpoints-in-interim-analysis-of-its-phase-3-ensemble-trial#_edn1
https://www.jnj.com/johnson-johnson-announces-single-shot-janssen-covid-19-vaccine-candidate-met-primary-endpoints-in-interim-analysis-of-its-phase-3-ensemble-trial#_edn1
Efficacy of Gamaleya Sputnik V rAd26 rAd5 two-shot vaccine interim analysis (after 21 days from first dose). (7/n)
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)00234-8/fulltext
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)00234-8/fulltext
Here is a great thread related to this by @MonicaGandhi9 
(8/n) https://twitter.com/MonicaGandhi9/status/1356818441064206337?s=20
(8/n) https://twitter.com/MonicaGandhi9/status/1356818441064206337?s=20
With all these vaccines, some approved, EUA, others soon to be approved, we can bring down the number of severe & lethal COVID. The variants are here, but current vaccines still protect from severe disease & vaccines for the variants are coming. We will get through this! (End)
