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#Efficacy
Peter Cayton, the Stats Guy
PJACaytonPhD
Note: I am a stats guy. The learning that I will share is based on interactions with experts far more knowledgeable than me (like @darwinbandoy).So, let's talk vaccines and numbers.
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Jamie Triccas
TricckyLab
1) With the release of Novavax data we are starting to get a good handle on how the level of immunity correlates with vaccine efficacy. So can use this to
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James One
james00000001
HERD IMMUNITY THREADMy superficial understanding:How To AchieveIt's achieved by enough people getting vaccinated, with a good average efficacy. E.g. 75% of people get 75% efficacy may work. Or 65% of
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Sizwe sikaMusi
SizweLo
What’s the difference between vaccine efficacy and effectiveness, and what do vaccine makers mean when they say their therapies are “95% effective”?[Thread] Vaccine efficacy refers to the percentage change in
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Eric Topol
EricTopol
Big news: The JNJ vaccine results of 44,000 Phase 3 trial, a single dose. Overall 66% efficacy, with the contrast of 72% in US but 57% in South Africa, confirming
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Gupta Lab, Cambridge
GuptaR_lab
Further data on immune responses following the Pfizer mRNA vaccine against pseudo virus bearing Spike protein with mutations in the B.1.1.7 variant (del69/70, del 144/145, N501Y, A570D, P681H, T716I, S982A,
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A Marm Kilpatrick
DiseaseEcology
FDA Pfizer/BioNTech vaccine efficacy results are great, but aren't nearly as great as presented for severe infections.Everyone has seen fig below on cases in vaccine (blue) & placebo (red) over
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whippletom
whippletom
Demographics of the South African study into Oxford vaccine Criteria for mild or moderate cases Neutralization data - immune responses "similar if not better" Efficacy, pre November. South African scientists
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Michael Mina
michaelmina_lab
VACCINES can work!Another #COVID19 phase 3 vaccine trial reports awesome results. This time, an estimated 94% efficacy95 COVID19 detected: only 5! in the vaccine group and 90 in the placeboBut
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Natalie E. Dean, PhD
nataliexdean
As @hankgreen nicely points out, we have to be careful that "we don't know whether the vaccine reduces transmission" doesn't morph into "the vaccine doesn't reduce transmission." How do we
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D-Money 🇹🇹
nerdclapback
1/Just finished reading the NEJM paper on the Pfizer mRNA vaccine. I've always maintained that seeing clinical trial data published in a peer reviewed journal of significance would be my
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The Lancet
TheLancet
NEW—First full results from interim analysis confirm that the Oxford #COVID19 vaccine is safe and efficacious against symptomatic COVID-19 disease: https://hubs.li/H0CcSs60 (1/6) The vaccine protects against symptomatic disease in 7
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Hilda Bastian, PhD
hildabast
Press conference on results of Brazilian trial of CoronaVac, Sinovac's inactivated vaccine, cleared up the efficacy data & made the complexity of comparing a trial in healthcare professionals with others
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Michelle Teplensky
DrMTeplensky
Scientists, we're only as good as our ability to communicate data to the public, so here goes my best shot. This graph is data from the Pfizer "BNT162b2 mRNA" Covid-19
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James Bloodworth
J_Bloodworth
Seems like those who reported this inflammatory story turned what's actually a legitimate criticism of the AZ process - a small trial sample for over-65s - into a ludicrous exaggeration
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tawanda chivese
TChivese
A quick word on the Sinopharm vaccine from China - seeing as there is so much debate on the TL The Sinopharm vaccine is made from a killed COVID-19 virus.
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