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Natalie E. Dean, PhD
nataliexdean
THINK LIKE AN EPIDEMIOLOGIST: Lately I have been asked why we are seeing a dramatic turnaround in cases in the US. Is it vaccines? Herd immunity? An artifact due to
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How do we measure how well the flu vaccine works every year? We use an observational study called the "test negative design." A few tweets on how it works, and
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Warning - some in-the-weeds tweets about vaccine efficacy trials, new strains, and decision making under uncertainty. I offer more questions than answers, but hopefully it can generate some discussion...1/6 For
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Oxford/AZ reports overall reduction in PCR positivity of 54.1%, but only 2% "vaccine efficacy against asymptomatic infection."Confused?Allow me to explain with crudely drawn pictures why the overall findings are still
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What is the best endpoint for Phase 3 vaccine trials? Disease of any severity? Severe disease? Infection? Most trials have selected the first, but this @PostOpinions piece is critical of
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A few tweets on a topic that keeps coming up in discussion. There are many different types of vaccine efficacy - efficacy against infection, against transmission, against disease, and against
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The conversation around vaccines feels jumbled because there are actually MANY policy ideas being floated:- One dose only vs. two doses spaced apart vs. two doses but don’t reserve the
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Our group's household secondary attack rate meta-analysis has gained traction, but not for the reasons I'd hoped for. We did not conclude "no asymptomatic or pre-symptomatic spread" of SARS-CoV-2. A
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As @hankgreen nicely points out, we have to be careful that "we don't know whether the vaccine reduces transmission" doesn't morph into "the vaccine doesn't reduce transmission." How do we
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Out in @TheLancet, results from the Oxford/AZN trials, including more detail on the low dose results. Notably, the low dose recipients "received their second dose after a substantial gap." Only
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Another exciting Monday morning for COVID-19 vaccines! Moderna is reporting 94.5% efficacy for their mRNA vaccine.Read on for a biostatistician's breakdown of the interim results. 10 tweets on severe disease,
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Tuning in now to hear about retrospective contact tracing. The goal -- interrupting chains of *clusters*!w/ Hitoshi Oshitani, @kj_seung, @zeynep https://cyber.harvard.edu/events/retrospective-contact-tracing-how-states-can-investigate-covid
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