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Gupta Lab, Cambridge
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The E484K has indeed arrived on the background of B.1.1.7 and detected thanks to @CovidGenomicsUK. This figure shows number of sequences deposited over time. There may be independent acquisitions which
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Following on from the first dose Pfizer data below where 7/15 participants above the age of 80 did not achieve neutralisation of virus, we report that all 15 have achieved
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Further data on immune responses following the Pfizer mRNA vaccine against pseudo virus bearing Spike protein with mutations in the B.1.1.7 variant (del69/70, del 144/145, N501Y, A570D, P681H, T716I, S982A,
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Sharing some real world data on antibody responses to the Pfizer mRNA vaccine. We tested serum from 23 participants (median age 82) vaccinated with the first dose 3 weeks previously.
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B1.1.7 has more than 20 changes in genetic code, of which 8 are in the Spike protein (shown below). Spike is the target of many of our immune and vaccine
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The UK SARS-CoV-2 multiply mutated variant VUI 202012/01 also has an interesting Spike deletion 69/70 we have been studying. The deletion is increasing in frequency (blue), as is the new
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Our analyses on the emergence and transmission of novel SARS-CoV-2 variants with deletions H69/V70 in Spike protein. We identified an increase in the frequency of SARS-COV-2 sequences with the H69/V70
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