#E484K

Theo Sanderson

theosanderson

1/ E484K in the UK. We seem to see E484K on at least 6 different backgrounds. B.1.351 and P.2 are imported lineages, originating in South Africa and Brazil. B.1.1.7 and

Gupta Lab, Cambridge

GuptaR_lab

The E484K has indeed arrived on the background of B.1.1.7 and detected thanks to @CovidGenomicsUK. This figure shows number of sequences deposited over time. There may be independent acquisitions which

Gill Dummigan

MsGillD

Spent today on @bbcnwt looking at the different variants and mutations of #COVID19 currently circulating around the north west. This may not interest you but here goes .... Viruses mutate

Mac n’ Chise 🧬🧫🦠

sailorrooscout

No data. Any variant may be able to reinfect people who have already had a previous infection. This is not new. No data it can evade vaccines. But getting vaccinated

Theo Sanderson

theosanderson

1/ Today has brought a lot of news about 'variants', as we discover community transmission of B.1.351 (SA variant) in the UK. But some of the people who study these

Dr Emma Hodcroft

firefoxx66

Following some increased interest tonight in S:E484, a new focal build is now up!This build is created by pulling out all sequences with a mutation at nucleotide 23012 & adding

Björn Meyer

_b_meyer

Seeing that B1.1.7 now acquired the E484K mutation in the UK, could we, at least for now, stop the narrative that this double mutation occurs by high immune pressure, please?because

Eric Feigl-Ding

DrEricDing

GOOD NEWS—a mutation seen in a few #SARSCoV2 variants doesn’t seem to harm the Pfizer/BioNTech vaccine, finding “no reduction in neutralization activity against virus”.HOWEVER—did not yet test for worrisome E484K

Eric Feigl-Ding

DrEricDing

Fauci: “We have to be concerned about the mutants” He’s right on the concern for the #B117, #B1351, #P1. Plus the B117+E484K mutant combination is worrisome. #COVID19 2) Here

Bloom Lab

jbloom_lab

Our complete mapping of mutations to #SARSCoV2 RBD that reduce binding by convalescent human plasma is out in @cellhostmicrobe (https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(21)00082-2). Right now E484K getting lot of attention

Vinci Zijun Wang

VinciZijun

Our newest data showed antibody and memory B cell responses in a cohort of 20 volunteers who received either the Moderna (mRNA-1273) or Pfizer/BioNTech (BNT162b2) vaccines. 1/https://www.biorxiv.org/content/10.1101/2021.01.15.426911v1 mRNA

Dr Zoë Hyde

DrZoeHyde

(1/6) This is quite a concerning development. An additional mutation (E484K; a key mutation in the South African variant) has now also been detected in a limited number of people

Just An Ordinary Bloke

Unusual_Times

A Laymans Guide to Mutations & Variants.I think we can beat covid in the UK if we really try. It's NOT endemic it's too young and it is still spreading

Bill Hanage

BillHanage

I think it is fair to say now that B.1.1.7 is definitely more transmissible, and possibly more virulent. This also reports cases that have acquired E484K, a mutation found in

Matt Raybould

mijr12

1/5 Growing evidence that E484 variants (e.g. SA variant) can largely escape evenly strongly neutralising serum from first wave (in past week, by Andreano et al. https://www.biorxiv.org/content/10.1101/2020.12.28.424451v1 and by Greaney

Eric Feigl-Ding

DrEricDing

WORRISOME & SERIOUS—You know how the world put travel bans against UK travel out of fear of the #B117 more contagious variant? Well, now, UK put travel ban from

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