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Our complete mapping of mutations to #SARSCoV2 RBD that reduce binding by convalescent human plasma is out in @cellhostmicrobe (https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(21)00082-2). Right now E484K getting lot of attention
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Our study mapping #SARSCoV2 mutations that escape key therapeutic monoclonal antibodies is out in @ScienceMagazine. The study also shows that some of these escape mutations arise in a persistently infected
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In this short thread, I am going to plot some experimental data in a way that provides perspective on concerns that #SARSCoV2 mutation E484K will completely abolish immunity. (Thanks @profshanecrotty
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We mapped how all mutations to #SARSCoV2 receptor-binding domain (RBD) affect recognition by convalescent polyclonal human sera (https://biorxiv.org/content/10.1101/2020.12.31.425021v1).Among implications: E484K (South African lineage) worr
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In new work, we show a human coronavirus evolves to escape neutralization by antibody immunity (https://www.biorxiv.org/content/10.1101/2020.12.17.423313v1). Specifically, we studied the historical evolution of the common-cold CoV-229E to l
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After posting our pre-print mapping #SARS_CoV_2 mutations that escape Regeneron antibodies, been getting questions about implications for therapies/vaccines. I'd like to contextualize results. Summary is don't be alarmed, but pay
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We mapped all #SARSCoV2 mutations escaping key antibodies used to treat #COVID19 (https://www.biorxiv.org/content/10.1101/2020.11.30.405472v1). Surprising observations: one amino-acid mutation escapes *both* antibodies in @Regeneron cocktai
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Excited to contribute to this extremely important #SARSCoV2 study by @GreningerLab that provides first direct evidence that neutralizing antibodies are a correlate of protection against #COVID19 in humans! (1/9)https://www.medrxiv.org/conte
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Our new study led by @khdcrawford in collaboration with @HelenChuMD looks at the dynamics of neutralizing antibodies in the 3-4 months following recovery from infection with #SARSCoV2 (1/9):https://www.medrxiv.org/content/10.1101/2020.08.06
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