#E484K

Getting a lot of questions about vaccines and variants and why @moderna_tx is developing a booster based on variant discovered in South Africa if vaccines are thought to protect against
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STUNNING—South African’s CDC has made a sobering declaration:“We now know that mutations (K417N & E484K) have allowed #SARSCoV2 to become resistant to antibody neutralization.”“Blood samples from *1/2 tested showed all
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SA variant and UK variant. Vaccinations and mutations. A thread: The South African variant (B1.351) was recently found in 8 places across the UK with no history of travel to
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REINFECTION & VACCINE SENSITIVITY—the concern is now growing very very real. This piece highlights the big S Africa CDC report I shared earlier, where antibodies from previously infected don’t
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DIFFERENCE A VARIANT CAN MAKE: Early in the Oxford-AstraZeneca’s South Africa trial, before #B1351 variant became dominant, the AZ vaccine had a great efficacy of 75% risk reduction of
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There's been a lot of news today about 'new variants in Brazil' & 'S:E484' and 'Ohio variants'. A short thread discussing what we know about each.1/11#SARSCoV2 #Ohio #BrazilVariant #Brazil #COVID19
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Bradford: covid wave 2Watching the Doctors and Nurses on Channel 4's news in Bradford Royal Infirmary is heartbreaking. They look shellshocked exhausted and helpless.I was born in one of the
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And now for the bad news. *sigh*It looks like #B117, the more transmissible variant first detected in England, has now picked up the E484K mutation as well. That is the
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We mapped how all mutations to #SARSCoV2 receptor-binding domain (RBD) affect recognition by convalescent polyclonal human sera (https://biorxiv.org/content/10.1101/2020.12.31.425021v1).Among implications: E484K (South African lineage) worr
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Our recent preprint of genetic epidemiology of #immune #escape variants from global #SARSCoV2 genomeshttps://www.biorxiv.org/content/10.1101/2020.12.24.424332v1 A number of genetic variants in #SARSCoV2 are associated with immune escape - a
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Very concerning report - 47 cases of the 501Y.V2 (variant arisen from South Africa) reported in surveillance within the UK. This is the variant with the E484K mutation that has
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#Variants. Thread. Aside- as they really seem to behave clinically differently, maybe we should call them strains? Anyway,also looking forward to naming conventions as it’s really inefficient to say B.1.1.7.
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It has not been a good news day when it comes to vaccines—particularly AstraZeneca—and the B.1.351 variant that arose in South Africa. But buried amidst the bad news of a
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SURGING #B117 WITHIN US—growing 7% per day, doubling every 9.8 days nationally, & expected to become dominant by March 23rd. It is surging fastest in Florida—doubling every 9.1 days. Scientists
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By naming 'a variant' we are flagging it as being of concern even if it probably isn't (relative to other circulating lineages). Back in April proposed a lineage naming system
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As horrific as #COVID19 looks right now, it is almost certainly about to get worse—“I’m very very concerned that we’ve now gone from a virus that we could control to
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