The E484K has indeed arrived on the background of B.1.1.7 and detected thanks to @CovidGenomicsUK. This figure shows number of sequences deposited over time. There may be independent acquisitions which is of concern but not surprising given B.1.351 and P1 both have it.
We generated 'pseudo' viruses bearing the Spike protein of SARS-CoV-2 that had all 8 B.1.1.7 mutations + E484K. We mixed virus with sera from vaccinated individuals (Pfizer) Overall, E484K substantially increases the amount of serum antibody needed to prevent infection of cells.
What does this mean? well the number of sequences is low at present, though enhanced surveillance is being undertaken by @PHE_uk. There may be more cases out there given how high transmission has been. We need to continue vaccinating and drive down transmission.
You can follow @GuptaR_lab.
Tip: mention @twtextapp on a Twitter thread with the keyword “unroll” to get a link to it.

Latest Threads Unrolled:
Those who think consciousness raising & movement building are disconnected, or even a distraction from electoral politics have not paid attention to the history of social change.In this thread, we
Read more
The 2020s will be known as the Remote Work decadeA few predictions of what is likely to emerge[ a thread ] Third Space: Office and Working from Home will
Read more
1/29: Have you ever had a concept explained to you that helps frame complex issues you’ve been wrestling with and opens your eyes to new possibilities? A concept that I
Read more
By continuing to use the site, you are consenting to the use of cookies as explained in our Cookie Policy to improve your experience.