#Platelet

Sudharshan

bundlbranchbloc

I got a call at lunch yesterday afternoon, from an unknown number. Imagining it to be a nursing staff calling about a patient, I picked up. Instead it was a

Dr Suzy M_rt_n 🅾️➕

TransfusionWM

Today I did an online tutorial with the West Midlands #haemSpRs. It was good to do some teaching after a bit of a hiatus! We've always done online tutorials on

Farid Jalali MD

farid__jalali

Pediatric Multisystem Inflammatory Syndrome of COVID19 is also a "platelet hyperactivation syndrome", just like Kawasaki's Disease is.The underlying pathophysiology is:Half of circulating platelet biogenesis occurs in lungs fr

Juliet Smith 🅰️➕

TransfusionGeek

Look at the difference in colour of these two platelet units… there’s an important reason why these two are so different but platelets do come in different colours, though they

Farid Jalali MD

farid__jalali

Yes. Platelets are those cells that in turn activate endothelium. There is a billion of these platelets and megakaryocytes PARKED in the lung microvascular space.https://www.biorxiv.org/content/10.1101/2020.11.08.372581v1 And there is an ov

Nicholas Morris

namorrismd

Nice study on Thrombocytopenia and Clinical Outcomes in Intracerebral Hemorrhage. Helps further delineate risks for poor outcome after ICH among patients on antiplatelet agents.https://www.ahajournals.org/doi/full/10.1161/STROKEAHA.120.0314

Farid Jalali MD

farid__jalali

Proper attention to 𝗮𝗹𝗹 aspects of pathology in COVID19, simultaneously, is paramount to proper treatment: pulmonary endothelium plateletsProducts of platelet-endothelial

Shematologist, MD

acweyand

New case report just published in the American Journal of Hematology of severe thrombocytopenia within days following #COVID19 vaccination. A https://onlinelibrary.wiley.com/doi/10.1002/ajh.261061/n The history is very similar to the report

Lisa Soto

lisarenee_RN

1/Why is the Platelet Count Low? Should I be Concerned About #Heparin-Induced Thrombocytopenia (HIT)?https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428184/ 2/Given the potential for morbidity and mortality HIT should always be considered in

CHEST Critical Care NetWork

CHESTCritCare

Let's start with #thrombocytopenia in the ICU #chestcritcare #thrombocytopenia is very common in the ICU, with 67% patients having it at admission to ICU and about 46% patients developing it

Bloodman

Bloodman

1/n Everybody seems to be very opinionated about thromboelastography! Here is how I view it and what I use it for……. 2/13 2/n TEG is a point of care test

Farid Jalali MD

farid__jalali

on serotonin, SSRIs, serotonin-blockers, and COVID19All causes of ARDS are associated with activation of resident lung platelets and megakaryocytes. The degree to which this activation occurs differs between various etiologies

Farid Jalali MD

farid__jalali

I refrain from recommending a cocktail, but at 200k cases per DAY now of COVID19, I think it may be time to go ahead:I think folks should consider taking an

Alex Berenson

AlexBerenson

1/ Okay, some real vaccine side effect data from a concerned physician with access to a big database (10000+ patients under 65). He compared ER visits of people in the

Dr Shane Comer👨🏻‍🔬💉

Shane_Comer1

1/New PublicationOur paper on RhoA regulation in human platelets is now available online @JTHjournal We show RhoA activity may not be regulated by direct PKA/PKG #phosphorylation but by #phosphorylation of

Farid Jalali MD

farid__jalali

COVID19 causes FLORID platelet activation, FAR beyond what ARDS typically causes. Platelet hyperreactivity in COVID19 is quantifiably higher than typical ARDS and exorbitantly higher than healthy individuals or admitted inpatients.

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