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New Publication
Our paper on RhoA regulation in human platelets is now available online @JTHjournal
We show RhoA activity may not be regulated by direct PKA/PKG #phosphorylation but by #phosphorylation of RhoA regulators GEF-H1 and Myo9b. https://onlinelibrary.wiley.com/doi/abs/10.1111/jth.15028
New PublicationOur paper on RhoA regulation in human platelets is now available online @JTHjournal
We show RhoA activity may not be regulated by direct PKA/PKG #phosphorylation but by #phosphorylation of RhoA regulators GEF-H1 and Myo9b. https://onlinelibrary.wiley.com/doi/abs/10.1111/jth.15028
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We found that RhoA #phosphorylation in #platelets is not as clear cut as we think.
It seems PKA/PKG target Myo9b S1354
its GAP activity in #platelets and PKA/PKG phosphorylate GEF-H1 S88614-3-3 binding &sequestration to #platelet #microtubules.
All leads to
RhoA-GTP
We found that RhoA #phosphorylation in #platelets is not as clear cut as we think.
It seems PKA/PKG target Myo9b S1354
its GAP activity in #platelets and PKA/PKG phosphorylate GEF-H1 S88614-3-3 binding &sequestration to #platelet #microtubules. All leads to
RhoA-GTP
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What this work 100% confirms is my love of #platelets
Many thanks to @JTHjournal, reviewers, our collaborators & @UCDMedicine for funding us (myself & my supervisor Albert Smolenski) & my #PhD!
What this work 100% confirms is my love of #platelets
Many thanks to @JTHjournal, reviewers, our collaborators & @UCDMedicine for funding us (myself & my supervisor Albert Smolenski) & my #PhD!
