#Allele

Joel McGlothlin

joelmcglothlin

Regarding a potential conceptual duality in the definition of fitness, I take the contrary view that it's important to use the same term because all definitions rely on the same

Cristobal Uauy

CristobalUauy

This is Triticum polonicum, a tetraploid wheat subspecies first described by Linnaeus in 1753 and which was instrumental in the study of quantitative variation by early geneticists such as Biffen.

Avraham Z. Cooper, MD

AvrahamCooperMD

1/15Why does alpha-1 antitrypsin deficiency (A1AT) cause liver disease (e.g. cirrhosis or hepatocellular carcinoma)?I always assumed the mechanism was the same as for lung injury and emphysema, but it's not.

Kaustubh Adhikari

kaustubhad

We've got a new preprint out! Looking into the prediction of skin, eye and hair colour in a diverse cohort beyond just European ancestry, especially into Native American ancestry, really

Fyodor Urnov

UrnovFyodor

1/[thread re sickle+thal wonderdata by @CRISPRTX]Marking in product ~80% (SCD), 78% (TDT) = 100% edited cells - huge win for the CMC team and bodes VERY well for future of

Kevin Bird

itsbirdemic

Last week @dr_appie stated the current consensus in human genetics that polygenic scores can't be compared between populations. He was met with some bold claims from the race science gang

cj battey

cj_battey

A thread of how I funded publications as a grad student and postdochttps://twitter.com/rsidd120/status/1336153828672983040 first two papers were in MPE, subscription only, lab paid ~$300 for color figures each (https://www.sciencedirect.com

Veera M. Rajagopal

doctorveera

Interesting GWAS of human ageing based on PCA analysis of multiple ageing phenotypes (mother and father life span, longevity etc.) https://www.biorxiv.org/content/10.1101/2021.01.22.427837v1 As I often recommend, here too effect size plot

Billy Bostickson 🏴👁&👁 🆓

BillyBostickson

1. TMEM41B - SARS-COV-2 - EAST ASIANS?TMEM41B transmembrane protein is a critical factor for SARS-CoV-2 replicationhttps://www.news-medical.net/news/20201210/Study-TMEM41B-transmembrane-protein-is-a-critical-factor-for-SARS-CoV-2-replicatio

The Autisticats

autisticats

Something I learned yesterday is that autistic children are 2x more likely than the general population to experience chronic pain. The article I read is right here, for anyone who

The Medical SHO

admit_medics

You’re the medical registrar on-call and receive a call from the psychiatry SHO as a patient has an adjusted calcium of 1.76. This is a 31 year old male currently

Simon Barnett

sbarnettARK

A Thread ()Let's discuss long-read #sequencing, optical mapping, and the implications of a recent study (linked below). Please view my disclosures at the end. I've intentionally made this thread more

Ewan Birney

ewanbirney

Today I am referencing again Tatuo Aida, 1921, Genetics 6. Title "On the Inheritance of Color in a Fresh-Water Fish, APLOCHEILUS LATIPES". https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1200522/pdf/554.pdf This is a landmark study b

David B. Lowry

DavidBLowry

I just wanted to take a moment to highlight the key results and story behind the science of a recent collaborative study out of my lab that was published this

Doc Edge

DocEdge85

(1) Last week, I posted the below thread on polygenic scores and have been pulled into almost-unrelated convos on Race and IQ since (my choice to engage, obv.) Here's a

Lucre Snooker

LucreSnooker

might fuck around and do a long detailed t-cell thread there's a lovely new paper that sheds a lot of light on CD8+ (aka killer/cytotoxic) T cells in COVID-19 and

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