1. TMEM41B - SARS-COV-2 - EAST ASIANS?
TMEM41B transmembrane protein is a critical factor for SARS-CoV-2 replication https://www.news-medical.net/news/20201210/Study-TMEM41B-transmembrane-protein-is-a-critical-factor-for-SARS-CoV-2-replication.aspx
Study: TMEM41B transmembrane protein is a critical factor for SARS-CoV-2 replication

A single protein that appears necessary for the COVID-19 virus to reproduce and spread to other cells is a potential weakness that could be targeted by future therapies.

https://www.news-medical.net/news/20201210/Study-TMEM41B-transmembrane-protein-is-a-critical-factor-for-SARS-CoV-2-replication.aspx
2. TMEM41B is a critical pancoronavirus host factor
We identified an absolute requirement for the VTT-domain containing protein TMEM41B for infection by SARS-CoV-2 & all other coronaviruses. https://www.biorxiv.org/content/10.1101/2020.10.07.326462v1
Genome-scale identification of SARS-CoV-2 and pan-coronavirus host factor networks

The COVID-19 pandemic has claimed the lives of more than one million people worldwide. The causative agent, SARS-CoV-2, is a member of the Coronaviridae family, which are viruses that cause respira...

https://www.biorxiv.org/content/10.1101/2020.10.07.326462v1
3. Please concentrate, this is important ;)
(from above paper)
3. Please concentrate, this is important ;)(from above paper)
3. Please concentrate, this is important ;)(from above paper)
4. Attractive Target...
5. TMEM41B
6. Lipid Membrane
7. Figures available here: https://www.cell.com/cell/fulltext/S0092-8674(20)31676-7
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks

Schneider et al. conducted parallel genome-wide CRISPR knockout screens with SARS-CoV-2 and three seasonal coronaviruses to identify pan-coronavirus and virus-specific host factor requirements. They...

https://www.cell.com/cell/fulltext/S0092-8674(20)31676-7
8. TMEM41B Is a Pan-flavivirus Host Factor https://www.cell.com/cell/fulltext/S0092-8674(20)31627-5
TMEM41B Is a Pan-flavivirus Host Factor

Hoffmann et al. determine that the transmembrane protein, TMEM41B, is required for infection by members of the Flaviviridae family of viruses. Loss of TMEM41B reduces viral RNA replication and...

https://www.cell.com/cell/fulltext/S0092-8674(20)31627-5
9. The East Asian Connection
10. TMEM41B single nucleotide polymorphisms (SNPs) 20% in East & SE Asian populations reduce flavivirus infection (and SARS-COV-2)
Nearly absent in European and African populations
∼3.5% frequency in the Latin American population
11. Exaggerated Immune Response !!!🥵🤒🤖!!!!
"TMEM41B-deficient cells display an exaggerated innate immune response upon high multiplicity flavivirus infection"
12. Scientists map the network of SARS-CoV-2’s helpers inside human cells
https://www.rockefeller.edu/news/29727-scientists-map-network-sars-cov-2s-helpers-inside-human-cells/
12. Scientists map the network of SARS-CoV-2’s helpers inside human cells https://www.rockefeller.edu/news/29727-scientists-map-network-sars-cov-2s-helpers-inside-human-cells/
12. Scientists map the network of SARS-CoV-2’s helpers inside human cells https://www.rockefeller.edu/news/29727-scientists-map-network-sars-cov-2s-helpers-inside-human-cells/
12. Scientists map the network of SARS-CoV-2’s helpers inside human cells https://www.rockefeller.edu/news/29727-scientists-map-network-sars-cov-2s-helpers-inside-human-cells/
13. Why does coronavirus kill fewer people in East Asia?
Several different hypotheses have been advanced
Diet, Physical Contact Culture, Mutations, Exposure to Bats and Covs historically, Obesity, Mandatory TB vaccinations, Selenium levels in Diet, etc https://www.dw.com/en/why-does-coronavirus-kill-fewer-people-in-east-asia/a-53781108
Does coronavirus kill fewer people in East Asia?

People in East Asia seem to be less likely than those in many other parts of the world to die of the coronavirus. But the explanations that have been put forward do not all hold water, as Martin...

https://www.dw.com/en/why-does-coronavirus-kill-fewer-people-in-east-asia/a-53781108
14. Apparent difference in fatalities between Central Europe and East Asia due to SARS-COV-2 and COVID-19: 4 hypotheses for possible explanation
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403102/
(Figures for deaths and cases as for May 2020)
14. Apparent difference in fatalities between Central Europe and East Asia due to SARS-COV-2 and COVID-19: 4 hypotheses for possible explanation https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403102/(Figures for deaths and cases as for May 2020)
14. Apparent difference in fatalities between Central Europe and East Asia due to SARS-COV-2 and COVID-19: 4 hypotheses for possible explanation https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403102/(Figures for deaths and cases as for May 2020)
14. Apparent difference in fatalities between Central Europe and East Asia due to SARS-COV-2 and COVID-19: 4 hypotheses for possible explanation https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403102/(Figures for deaths and cases as for May 2020)
15. Other SARS-COV-2 mortality - severity -genetic - ethnic factors considered to date
Mainly Toll Like Receptor Immune Response https://twitter.com/BillyBostickson/status/1287653967917273089
16. Other possible proposed factors
1. human leukocyte antigen (HLA) polymorphisms
2. human Angiotensin-converting enzyme 1 (ACE1) gene on chromosome 17
3. ACE1/ACE2 Imbalancec- D Allele
4. CCR5-Δ32 allele frequencies
5. Blood Type
https://www.medpagetoday.com/infectiousdisease/covid19/89117
16. Other possible proposed factors1. human leukocyte antigen (HLA) polymorphisms2. human Angiotensin-converting enzyme 1 (ACE1) gene on chromosome 173. ACE1/ACE2 Imbalancec- D Allele4. CCR5-Δ32 allele frequencies5. Blood Type https://www.medpagetoday.com/infectiousdisease/covid19/89117
16. Other possible proposed factors1. human leukocyte antigen (HLA) polymorphisms2. human Angiotensin-converting enzyme 1 (ACE1) gene on chromosome 173. ACE1/ACE2 Imbalancec- D Allele4. CCR5-Δ32 allele frequencies5. Blood Type https://www.medpagetoday.com/infectiousdisease/covid19/89117
16. Other possible proposed factors1. human leukocyte antigen (HLA) polymorphisms2. human Angiotensin-converting enzyme 1 (ACE1) gene on chromosome 173. ACE1/ACE2 Imbalancec- D Allele4. CCR5-Δ32 allele frequencies5. Blood Type https://www.medpagetoday.com/infectiousdisease/covid19/89117
16. Other possible proposed factors1. human leukocyte antigen (HLA) polymorphisms2. human Angiotensin-converting enzyme 1 (ACE1) gene on chromosome 173. ACE1/ACE2 Imbalancec- D Allele4. CCR5-Δ32 allele frequencies5. Blood Type https://www.medpagetoday.com/infectiousdisease/covid19/89117
17. Other research on genetic factors from:
http://Covid19hg.org 
https://www.covid19hg.org/blog/2020-10-28-twas-working-group/
and slides
https://www.covid19hg.org/blog/2020-10-05-october-2-2020-meeting/
and the Nature Neanderthal Gene Study
https://www.nature.com/articles/s41586-020-2818-3
17. Other research on genetic factors from: http://Covid19hg.org  https://www.covid19hg.org/blog/2020-10-28-twas-working-group/and slides https://www.covid19hg.org/blog/2020-10-05-october-2-2020-meeting/and the Nature Neanderthal Gene Study https://www.nature.com/articles/s41586-020-2818-3
17. Other research on genetic factors from: http://Covid19hg.org  https://www.covid19hg.org/blog/2020-10-28-twas-working-group/and slides https://www.covid19hg.org/blog/2020-10-05-october-2-2020-meeting/and the Nature Neanderthal Gene Study https://www.nature.com/articles/s41586-020-2818-3
18. Above all genetic factors listed above, a clear winner emerges: TMEM41B transmembrane protein.
This unfortunately raises a disturbing question:
Unroll "TMEM41B, Cui Bono?" @threadreaderapp
Not claiming SARS-COV-2 = bioweapon crafted to kill non-Asians, but, well, just but!
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