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Veera M. Rajagopal
doctorveera
India has a high genetic diversity. Do you know what shaped this diversity? If your guess is geography, you're wrong. @AritraBose90 and team show the present day genetic structure of
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Interesting GWAS of human ageing based on PCA analysis of multiple ageing phenotypes (mother and father life span, longevity etc.) https://www.biorxiv.org/content/10.1101/2021.01.22.427837v1 As I often recommend, here too effect size plot
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This is an ingenious paper. No doubt about that. But it is getting media attention for the wrong reasons. 1/8https://www.nature.com/articles/s41588-020-00755-1 This paper is one of 100s of papers from deCODE
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Four important papers published in 2020 beautifully demonstrated in what ways PRS will be used in clinic in the near future. A thread. 1. PRS is often seen as a
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Can genetic score based on predicted gene expressions offer better prediction than polygenic scores?Short answer: no (at least not with the existing eQTL datasets, which are based on bulk-tissue RNAseq)A
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This impressive single cell study profiled every stage of beta cell development (from embryonic stem cells to mature beta cells) and beautifully demonstrates that many GWAS identified T2D genes are
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