#N501Y

Eric Topol

EricTopol

1. Structural biology has been a standout in the pandemic, mapping the virus, antibodies and vaccines atom by atom. So I had a conversation with one of its leaders, Andrew

Just An Ordinary Bloke

Unusual_Times

Bradford: covid wave 2Watching the Doctors and Nurses on Channel 4's news in Bradford Royal Infirmary is heartbreaking. They look shellshocked exhausted and helpless.I was born in one of the

Dr Emma Hodcroft

firefoxx66

Is the new UK variant the same as the new South African variant (501Y.V2)?No.They both share the same mutation in spike: N501Y (N->Y at position 501). However, the 2 variants

Kai Kupferschmidt

kakape

Situation with new #sarscov2 variants is becoming harder to follow (and not just because of the names), so let me try and give a brief overview: Where are we at?

Dr Emma Hodcroft

firefoxx66

As far as I know, the #SARSCoV2 variant identified by Hancock today is defined by a spike mutation at position 501 N->Y & a double-deletion at positions 69/70.You can see

Dr. Angela Rasmussen

angie_rasmussen

Hard agree. And if this is useful, let me share something that often gets omitted (not by @kakape).Variants always emerge, & are not good or bad, but expected. The challenge

Bill Hanage

BillHanage

There is a new ‘variant’ clearly identified today, P.1. And it is worth saying a little about what we have learned about it, and from the variants we have identified

Aaron Derfel

Aaron_Derfel

1) While other provinces are providing detailed breakdowns on the number of #COVID19 variants, confusion and a lack of information persist in Quebec about the more transmissible strains. In this

Robert Dingwall 🏴󠁧󠁢󠁳󠁣󠁴󠁿 🇪🇺 Reunite

rwjdingwall

There is currently a great deal of fear-mongering about Christmas visits in the UK. In order to assess the risk associated with a family or social visit within the rules,

Prof Francois Balloux

BallouxFrancois

We previously analysed recurrent #SARSCoV2 mutations for an association with increased transmission using ~47k genomes. At the time, we found no evidence for any mutation making the virus intrinsically more

Trevor Bedford

trvrb

First, some background. RNA viruses all evolve extremely rapidly, but some like influenza are able to accept mutations to their surface proteins in such a way that they can partially

Dr. Faran Ahmad ⚕️🆔

drfaranahmad

SARS-CoV-2 is getting all these strange mutations . Do I need to get worried, as the vaccine may not work?? The simple answer is: Mostly Likely NO - SARS-CoV-2 is

Trevor Bedford

trvrb

With #COVID19 vaccine efficacy of ~95%, I'm looking forward to vaccine distribution in 2021 bringing the pandemic under control. However, I'm concerned that we'll see antigenic drift of SARS-CoV-2 and

Kai Kupferschmidt

kakape

And now for the bad news. *sigh*It looks like #B117, the more transmissible variant first detected in England, has now picked up the E484K mutation as well. That is the

Dena Grayson, MD, PhD

DrDenaGrayson

WORRISOME: infections in the UK soar with mutant #coronavirus strain B.1.1.7 that appears to spread more easily between people.#B117 strain acquired 17 mutations *all at once* (including 8 in the

Eric Feigl-Ding

DrEricDing

REINFECTION & VACCINE SENSITIVITY—the concern is now growing very very real. This piece highlights the big S Africa CDC report I shared earlier, where antibodies from previously infected don’t

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