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Rajeev Venkayya MD
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THREAD: Vaccine ManufacturingBack in October, I said the Warp Speed timelines were extraordinarily optimistic given the inherent risks of vaccine development, manufacturing and distribution. All of those risks and others
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Agree with this piece and the "strawman" messaging at the end. One clear opportunity is to focus on prevention of severe disease and death (where most vaccines are very efficacious)
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This is a really important point. I suspect many think a vaccine may not work after a delayed 2nd dose. In all likelihood, a delayed second dose would offer *better*
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THREADI created a simple table to illustrate the individual impact of the "flexible second dose timing" now recommended in the UK.Coincidentally, @bob_wachter & @ashishkjha just tackled the US policy question
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THREADThere’s much debate around the UK's recommended use of the AZ vaccine with a two-dose schedule and flexible timing of second dose. Some thoughts on the AZ recommendation (not Pfizer)
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I've participated in some great discussions on #COVID19 and #vaccines on #Clubhouse recently. I’ll use this thread to share some references I’ve mentioned and/or plan to bring up in future
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THREADHow were the first #CovidVaccines developed in less than a year without cutting corners?The vast majority of vaccine development time is spent *preparing for* Phase 3: the final large-scale, costly,
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Excellent analysis of the Moderna news from @nataliexdean. Some thoughts on the implications for #COVID #vaccines in general, reflecting my personal views only. Disclosures at the end. 1/https://twitter.com/nataliexdean/status/1328356802380
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THREADIn light of the Pfizer #vaccine news, a natural question is whether it's feasible to develop “better” #COVID19 vaccines after the first ones are approved?The answer is yes. It can
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This is very good news indeed, and the *potential* implications go well beyond the @pfizer #COVID19 vaccine. While we just have the press release, it's worth reviewing what this *could*
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Great question, but not a simple answer!I’m not a QA/CMC/manufacturing expert but I oversee those groups. You can’t separate QA from manufacturing, so first some general background on vaccine manufacturing
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Great explainer from @ashishkjha, expanding on what @michaelmina_lab and others have been saying.No public health intervention is perfect or achieves 100% compliance. But when applied in combination across a population,
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