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c0nc0rdance
c0nc0rdance
Hi Matthew, I'm a cancer biologist, and we use the evolutionary model every day to understand cancer progression at the cellular level.Inherited changes in tumor cells produce populations that diversify
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Nik Joshi
Joshilabyale
I’m excited to announce that our paper showing how tumor draining lymph nodes contain a long-term, stable reservoir of anti-tumor CD8 T cells is now online at @biorxiv. This is
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Nik Joshi
Joshilabyale
A tweetorial on our recent pre-print. This work started with a basic question about what B cells and T follicular T cells do in lung cancer. We and others saw
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brendan
brendan_49
The rationale for ROR1 as CAR-T target:1) Expression restricted to fetus and tumors. If ADC's are safe CARs should be too.2) ADCs nabbed monotherapy CRs in MCL.3) Diverse tumors evolve
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Amy Wisdom
AmyWisdom8
Excited to share that our paper is out today in @NatureComms https://www.nature.com/articles/s41467-020-19917-0. A great collaboration from @DKirschMDPhD @YvonneMowery @DukeRadOnc @DukeCancer and @Barzin_@max_diehn @StanfordCancer examining
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Brian Cox, MD, MAS
Dr_Brian_Cox
Name the following tumor of neural crest origin: Is this a: Paraganglioma...showing the nested "zellballen" growth pattern with vascularized fibrous stroma. We use synapto/chromo/CD56 to highlight tumor cells. Sustentacular cells
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Karen Pinto DNB, FRCPath
TheKarenPinto
A #PathQuiz on the #CAPProtocol of cancers of the anus#pathology #GIPath1. According to WHO, squamous cell carcinoma (SCC) of the anus should be subtyped as: large cell keratinizing, large cell
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Roxy Striar
roxystriar
THIS THREAD IS WORTH YOUR TIME & MEANS THE WORLD TO ME:Today is #GBMDay — the 2nd annual Glioblastoma Awareness Day. Glioblastoma is an extremely aggressive type of brain cancer
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The Pittet Lab
PittetLab
Happy to share our latest work on tumor-infiltrating dendritic cells (DC)! https://doi.org/10.1084/jem.20200264 We know these cells can play key antitumor functions, but they require more attention and could become important
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Pharm. D
Pharmdca
$MREO Thread1)Focus of this thread: Etigilimab and AlvelestatFinancials: Roughly $200 million in cash (50M from upfront payment from Ultragenyx & $115M raise from a strong secondary last week). Company fully
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Patrik Simmler
PatrikSimmler
I am happy to share our preprint about the #splicing factor SF3B1 that contributes to tumor malignancy by facilitating the adaption to hypoxia in solid cancers. SF3B1 interacts with #HIF1α
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Sri Krishna
tellkrish
With @franklowery our new study on attributes of T cells that contribute to successful cell therapy in cancer patients in @ScienceMagazine today w/ colleagues @slgoff_SB, @NCI_CCR_SB @theNCI a TL;DR thread
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Sandip Patel MD
PatelOncology
KEYNOTE-158 study out in Lancet Oncology, Pembrolizumab for TMB>10- most data time date we have seen since FDA approval, key aspects include tumor types studiedhttps://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(20)30445-9/fu
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Simon Barnett
sbarnettARK
Let's discuss a key aspect of vertical integration for diagnostics companies involved in #oncology testing:Synthetic Biology (#SynBio) We think maximum operating leverage will accrue to those companies who have bought,
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Ryan Reeves
investing_city
Genomics Thread #6Let's talk about liquid biopsies... 1/ A liquid biopsy is usually a blood-based test that can detect cancer. How?By detecting either CTC (circulating tumor cells) or ctDNA (circulating
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Simon Johnston
cancerdocsi
Lobular disease accounts for more than 1 in 10 cases of breast cancer. It is often referred to as the sneaky subtype because it can evade detection. A lot has
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