I am happy to share our preprint about the #splicing factor SF3B1 that contributes to tumor malignancy by facilitating the adaption to hypoxia in solid cancers. SF3B1 interacts with #HIF1α and acts as a transcriptional co-activator. -> Thread (1/4)
https://www.biorxiv.org/content/10.1101/2020.11.10.376780v1
We limited Sf3b1 expression in a mouse model of #PancreaticCancer, leading to severely reduced tumor growth. This is due to reduced capability of #cancer cells to adapt to #hypoxia, while splicing remains functional. The image shows tumors with high and low levels of Sf3b1. (2/4)
We also identified high SF3B1 expression as a risk factor in many solid cancer types. Thanks to the efforts of our collaborators at @Unispital_USZ we could validate our findings in a large cohort of kidney cancer patient samples. (3/4)
This manuscript is dedicated to the memory of Prof. Wilhelm Krek, who initiated the project. Big thanks to Cédric Cortijo, the co-first author, @schwanklab, @lisa__koch, @gxr and all the amazing collaborators! (4/4)
You can follow @PatrikSimmler.
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