#Placebo

Keith R. Holden, MD

KeithHoldenMD

Several studies suggest that a placebo administered without deception, non-deceptive placebo (NDP), can help people manage emotional distress and clinical disorders. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008733/https://www.ncbi.nlm.

Matt McCarthy

DrMattMcCarthy

Vaccine Dilemma: When should volunteers who received placebo get the real thing? If vaccines are highly effective, it seems unethical to withhold inoculation from people who bravely volunteered for a

Jesse O’Shea MD, MSc

JesseOSheaMD

I've been getting a lot of questions of how the Pfizer's COVID19 vaccine side effect profile compares to other common vaccines. So - I made some graphics. Pfizer's vaccine has

Johannes Haushofer

jhaushofer

Here's what I think it means that the new @pfizer/@BioNTech_Group vaccine has an effectiveness of 90%. They define effectiveness as VE=100*(1-IRR), where IRR is the infection rate ratio, i.e. the

WheatNOil

WheatNOil

These graphs are on the effectiveness of the two mRNA vaccines and they are, in a word, incredible.Going from left to right is days from the ‘first dose’ of the

🍿Popcorn at the Ready🍿

StuBeale

1/ Onion TeaPlacebo or CURE for COVID?My COVID-19 story starts on Thursday 12/10. Out of the blue, a friend I hadn't heard from since 2016 texted me, told me of

Max Kennerly

MaxKennerly

FYI, if you see declarations about new COVID variants evading immunity:1) this isn't about the vaccines, which work against the variants2) the issue is naturally acquired immunity, based on placebo

Carl T. Bergstrom

CT_Bergstrom

A somewhat technical thread about measuring vaccine efficacy.We're used to the notion that certain properties of tests for disease depend on prevalence: positive and negative predictive value do, for example,

Jaimie Ding

j_dingdingding

So my mom found this article and was panicking - because it said the Pfizer vaccine “was 74.4% effective in Asian Americans” without any explanation or note. This is /extremely

Alex Berenson

AlexBerenson

1/ The @NEJM paper on the @pfizer vaccine has worrying details. The authors note "serious adverse events" are similar in vaccine (0.6%) and placebo (0.5%); they admit only in an

Holly Fernandez Lynch (she/her)

HollyLynchez

Clearest explanation I have seen to date on how Pfizer plans to handle its placebo participants. Posted in the FDA EUA decision memo, which seems to have been posted since

Edward Nirenberg

ENirenberg

So I'm told that there's some confusion going on about what placebos for vaccine trials should be.Let's chat about this one. It's really common to hear from anti-vaccine people that

Alex John London

AlexJohnLondon

We run trials of vaccines to learn about (at least) two things: does the vaccine offer a protective effect and how safe is it. But we don’t just care about

𝔻𝕣𝕃𝕪𝕟𝕟𝔽𝕪𝕟𝕟 🇺🇸 👩🏽‍⚕️🧬💊🥼🩺🦠🌿

LynnFynn3

1) Doing a little light reading... The @Pfizer Study (as well as the other Covid-19 Trials) is a disgrace. Inject 44,000 subjects, half with placebo... they analyzed 94 “positive” cases...no

C. Michael Gibson MD

CMichaelGibson

I have questions:1. The follow-up is 2 years after the 2cd dose in the Moderna trial. You cannot enroll if you plan to get another vaccine.If I get randomized to

Eric Feigl-Ding

DrEricDing

BREAKING—Moderna just announced its experimental coronavirus vaccine is nearly 95% effective at preventing illness, including severe cases, in preliminary analysis. And of 11 observed severe cases, all were in the

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