#GWAS

Our manuscript on MedRvix describes a large GWAS in Alzheimer: 33 new loci and 42 in a next update https://www.medrxiv.org/content/10.1101/2020.10.01.20200659v1.This week, Wightman et al. described that they called the largest
Read more
This impressive single cell study profiled every stage of beta cell development (from embryonic stem cells to mature beta cells) and beautifully demonstrates that many GWAS identified T2D genes are
Read more
ICYMI*, we had a new paper come out in @NatureGenet last week: a GWAS of "noncognitive skills," a construct that nearly everyone can agree is important, but no one can
Read more
Welcome all! We've added several hundred followers over the past few weeks, so as a quick intro, I use this account mainly to explore interesting issues related to the biological
Read more
This will present work from ERICA-SA – Evolving Risk Factors for Cancers in African Populations where I’m a proud collaboratorStudying breast, oesophageal squamous & cervical cancer.Funded by South Africa MRC
Read more
1/[thread re sickle+thal wonderdata by @CRISPRTX]Marking in product ~80% (SCD), 78% (TDT) = 100% edited cells - huge win for the CMC team and bodes VERY well for future of
Read more
Kidney disease genetic risk variants alter lysosomal beta-mannosidase (MANBA) expression and disease severity https://stm.sciencemag.org/content/13/576/eaaz1458 The study is lead by @Xiangchen_Gu @XinSheng7 and Holly Yang. Kidney function G
Read more
A short thread on this interesting new paper.Transferring polygenic risk scores (PRSs) across populations is one of the most urgent problems in the field. The idea presented here is perhaps
Read more
Happy to share my first first-author manuscript as a post-doc on @biorxivpreprint with @silParacchini and @f_abbondanza conducted at @StAndMedicine.https://www.biorxiv.org/content/10.1101/2020.07.22.215376v1 We report behavioural and geneti
Read more
excited the @ChowLab's newest paper! Another installment in trying to understand NGLY1 deficiency #NGLY1 #RareDisease #openaccess Before I get into the paper, I'm really proud of the team effort to
Read more
Beyond excited to share new PREPRINT I co-1st authored with @smarek0502 . Using #ABCDStudy data, we show that the effect sizes of brain-wide associations and sampling variability are a key
Read more
Interesting GWAS of human ageing based on PCA analysis of multiple ageing phenotypes (mother and father life span, longevity etc.) https://www.biorxiv.org/content/10.1101/2021.01.22.427837v1 As I often recommend, here too effect size plot
Read more
Here to interrupt your doom-scrolling with our latest pre-print about #tomato steroidal alkaloids and genetic diversity! Why care? Take 30 seconds to find out.. https://www.biorxiv.org/content/10.1101/2021.01.06.425594v1 People have known f
Read more
Two comments on the claim that the chr3 COVID risk factor is introgressed from Neanderthals: https://www.biorxiv.org/content/10.1101/2020.07.03.186296v1.full.pdf 1. The haplotype certainly looks Neanderthal, but the indel that is the lead v
Read more
Last week @dr_appie stated the current consensus in human genetics that polygenic scores can't be compared between populations. He was met with some bold claims from the race science gang
Read more
This one was extra tough but I think I may have discovered a droplet of insight, so if you're ready, let's dive in! https://twitter.com/SbotGwa/status/1335207398135443458 Although there are at least two
Read more
By continuing to use the site, you are consenting to the use of cookies as explained in our Cookie Policy to improve your experience.