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Nick Mark MD
nickmmark
Exciting results from the #RECOVERY trial #preprint of #Tocalizumab (Toci) in hospitalized people w/ #COVID19-reduced 28-day mortality (29 vs 33%; NNT)-decreased likelihood of requiring MV (33% vs 38%)-shorter hospital stay
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Interesting (unpublished) results from ATACC/ACTIV4/REMAP-CAP #COVID19 studies-therapeutic #anticoagulation (TA) reduced organ failure support days in non-ICU patients but had no benefit in ICU patients-no mortality reduction with TA in eit
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Long awaiting #COLCORONA RCT now in #PrePrint:-4488 non-hospitalized pts with suspected #COVID19 randomized to #colchicine (0.5 mg BID x3)vs placebo-1° outcome (composite death/hospitalization) was NOT significant-interesting findings in s
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Here’s a #tweetorial about extremes of #physiology that are very much "compatible with life".Case #1. You are called about a critical drop in platelets. Platelet Count (x10^3/uL)Previous 475
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Meta-analysis of antibiotic prescribing in #COVID19 inpatients finds:-74.6% received antibiotics -8.6% had bacterial co-infection At first glance, this suggests that we’re *way* overprescribing Abx in COVID. But there
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It kinda irks me when someone describes a vital sign or lab value as “incompatible with life.”Here’s a @tweetorial all about the extremes of physiology.Case #1:A 10 yo ____ presents
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On 9/11/01 I was a senior in high school in Brooklyn. I had a front row seat as planes flew into the WTC, murdering thousands & altering the course of
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Lots of articles about ICUs reaching capacity, but what does this actually mean?Buckle up for a #tweetorial about ICU capacity and what it means in the context of #COVID19.1/ First,
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Pre-print of #RECOVERY RCT shows actual data about reduced #COVID mortality with #Dexamethasone: - mortality 21.6% compared to 24.6% w/ usual care- greatest benefit in sickest patients- for pt on
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