From serology studies it is estimated that 80 to 100 million Americans have had covid-19 infections. New data from @florian_krammer and colleagues suggests that, with + antibody testing, 1 dose of vaccine may be a viable strategy to achieve protection https://www.medrxiv.org/content/10.1101/2021.01.29.21250653v1.full.pdf
Which is why many people getting their 1st dose of the mRNA vaccines have the expected side-effect profile of the 2nd dose. In the mRNA vaccine trials, only 2-3% of the participants were determined to be seropositive after enrollment.
I've been advocating the use of rapid, quantitative antibody testing to promote the optimal use of our vaccine supply, limited in the short term, while assuring maximal protection: https://twitter.com/EricTopol/status/1351655082928951296
More on this preprint, important topic of ? 2nd dose (and side effects in 1st-dose that simulate 2nd dose) in those with previous covid, by @cwillyard
https://www.nytimes.com/2021/02/01/health/have-you-had-covid-19-coronavirus.html w/ @VirusesImmunity "So one dose is probably more than enough" @florian_krammer
and @sromano23
You can follow @EricTopol.
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