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It sounds a bit homeopathic but the more I read into metabolism and inflammation and circadian physiology the more I seriously worry about feeding our patients continuously and overnight a) it uses a lot of oxygen to display ATP dependent transporters 24/7 (we don't usually!)
B) feeding is a significant way of entraining the circadian clock which uses NAD (the molecule we protonate via the Kreb's cycle and represents starvation in its non protonated form
How can we give melatonin and feed all night that is bonkers. Circadian disruption leads to a lot of delirium and post icu sleep issues.
C) almost no organism in the world is in a constant growth cycle. They feed and rest, active and rest. Even cancer cells take time to build new proteins etc!
D) high/constant NADH levels (fed state) unregulate TNFa through a gene promotor, which of course causes muscle catabolism.
I know there's a calorie content but this all just doesn't work overall, can't ignore physiology/biochemistry that goes back to primordial soup. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608947/
And in care you weren't convinced, how feeding also maps mitochondrial activity to day and night https://science.sciencemag.org/content/342/6158/1243417
And how ageing relates to NAD/NADH levels (the way that resveratrol helps influence ageing in mice) https://www.nature.com/articles/s41580-020-0254-8
Please can we just not mess with this basic wiring and find something else to do.
For the cynics this does all happen in people too
