Connecting the dots between RSV, F, erection, S, and 2P's
1. The @McLellan_Lab work on RSV virus to stabilize the F protein (which may lead to successful vaccines)
From https://www.newyorker.com/magazine/2021/01/04/the-plague-year @NewYorker by @lawrence_wright

2. The @ScienceMagazine paper in 2013 that was, in retrospect, a frontrunner for coronaviruses and #SARSCoV2 sharing the property of membrane fusion and the need to stabilized the fusion protein to get effective vaccines
https://science.sciencemag.org/content/sci/342/6158/592.full.pdf

3. That was by X-ray crystallography which didn't enable visualization of the spike (S) protein of coronaviruses until this @nature publication by @WardLab1 @McLellan_Lab @KizzyPhD and colleagues in 2016 via cryo-EM https://www.nature.com/articles/nature17200

4. Which laid the foundation for stabilization of the S protein via the 2-proline substitution (2P) by @goodwish916
subthread https://twitter.com/erictopol/status/1338210550740762624?lang=en

5. More on this remarkable discovery leading to stabilization of S and the high efficacy of #SARSCoV2 vaccines (~50X neutralizing antibody production cf no 2P substitution)
podcast w/ @WardLab1 https://twitter.com/erictopol/status/1341807184460402688?lang=en