Does #SARSCoV2 directly infect @brain cells?
A brief review of the evidence
1. An exhaustive @TheLancetNeuro clinical review suggested this but w/ little supportive data https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(20)30221-0/fulltext
A brief review of the evidence
1. An exhaustive @TheLancetNeuro clinical review suggested this but w/ little supportive data https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(20)30221-0/fulltext
2. The mechanism for loss of smell has invoked both direct viral invasion of the olfactory bulb and indirect effects
Direct https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2769496 @JAMAOto
Indirect
https://advances.sciencemag.org @ScienceAdvances
Direct https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2769496 @JAMAOto
Indirect
https://advances.sciencemag.org @ScienceAdvances
3. A very recent, in-depth review of the pathogenesis of #SARSCoV2 and the nervous system concluded the evidence is inconsistent
http://www.cell.com/cell/retrieve/pii/S0092867420310709?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867420310709%3Fshowall%3Dtrue @CellCellPress
http://www.cell.com/cell/retrieve/pii/S0092867420310709?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867420310709%3Fshowall%3Dtrue @CellCellPress
4. A preprint this week by @YaleMed @YaleIBIO @ericsongg @VirusesImmunity looked at this question in 3 ways: autopsy of brain tissue positive for virus, organoids, and a mouse model, all quite supportive of direct infections https://www.biorxiv.org/content/10.1101/2020.06.25.169946v2
5. The invasive potential of #SARSCoV2 to infect brain cells could be elucidated in the organoid or mouse model, whereby antibodies to ACE2 or CSF from a #COVID19 patient inhibited, and overexpressed hACE2 mice facilitated
6. The important study was summarized and translated by @apoorva_nyc @NYTScience
https://www.nytimes.com/2020/09/09/health/coronavirus-brain.html?searchResultPosition=1
https://www.nytimes.com/2020/09/09/health/coronavirus-brain.html?searchResultPosition=1