Read on Twitter
1. The early use of inhaled interferons is emerging as a promising strategy to prevent severe #COVID19: lines of support include mechanism, rare genomic variants, a multicenter retrospective report, and a small randomized trial
2. On mechanism, our innate immune response, first line of defense relies, at least in part, on the interferon response.
2 figures from @VirusesImmunity's terrific thread, and the link to it
https://twitter.com/VirusesImmunity/status/1285944893085491204
2 figures from @VirusesImmunity's terrific thread, and the link to it
https://twitter.com/VirusesImmunity/status/1285944893085491204
3. Yesterday's @JAMA_Current report of loss-of-function TRL7 rare variants in 4 young men from 2 independent families w/ severe #COVID19 connects with their impaired interferon response
Editorial @rplenge https://jamanetwork.com/journals/jama/fullarticle/2768925
Paper by @ahoischen et al https://jamanetwork.com/journals/jama/fullarticle/2768926
Editorial @rplenge https://jamanetwork.com/journals/jama/fullarticle/2768925
Paper by @ahoischen et al https://jamanetwork.com/journals/jama/fullarticle/2768926
4. Multicenter report of inhaled interferon-alpha2b (Type1) showed benefit if given early, harm if late (opposite of pattern with dexamethasone)
https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(20)30401-7 @cellhostmicrobe
https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(20)30401-7 @cellhostmicrobe
5. A small randomized trial of inhaled beta interferon in 100 patients, only available via press release so far, but very encouraging
results https://www.synairgen.com/wp-content/uploads/2020/07/200720-Synairgen-announces-positive-results-from-trial-of-SNG001-in-hospitalised-COVID-19-patients.pdf
and important caveats here, by @benjmueller
https://www.nytimes.com/2020/07/20/world/covid-19-treatment-synairgen-interferon-beta.html
results https://www.synairgen.com/wp-content/uploads/2020/07/200720-Synairgen-announces-positive-results-from-trial-of-SNG001-in-hospitalised-COVID-19-patients.pdf
and important caveats here, by @benjmueller
https://www.nytimes.com/2020/07/20/world/covid-19-treatment-synairgen-interferon-beta.html
6. There are dozens of ongoing trials, an overview by @meredithwadman @ScienceMagazine https://science.sciencemag.org/content/369/6500/125
but if this holds up it will be the first class of drugs that can be given early in the course of an infection, fulfilling a major unmet need
but if this holds up it will be the first class of drugs that can be given early in the course of an infection, fulfilling a major unmet need
2 points to add:
—a @pbleic thread on the biology of TLR7, interferons and another ? contributor for the
vulnerability in men
https://twitter.com/pbleic/status/1287002569324150785
—thinking about rapid #SARSCoV2 testing and early inhaled interferon to change the natural history of infections is exciting
—a @pbleic thread on the biology of TLR7, interferons and another ? contributor for the
vulnerability in menhttps://twitter.com/pbleic/status/1287002569324150785
—thinking about rapid #SARSCoV2 testing and early inhaled interferon to change the natural history of infections is exciting
I forgot to include this important, relevant study https://science.sciencemag.org/content/sci/early/2020/07/10/science.abc6027.full.pdf @ScienceMagazine
by @TerrierBen and colleagues
Deficient Type 1 interferon response correlation with clinical severity
by @TerrierBen and colleagues
Deficient Type 1 interferon response correlation with clinical severity
More on interferon therapy @sciam today, perspective on @TerrierBen study and others in this thread,, importance of timing
https://www.scientificamerican.com/article/an-immune-protein-could-prevent-severe-covid-19-if-it-is-given-at-the-right-time/ by @elandhuis
https://www.scientificamerican.com/article/an-immune-protein-could-prevent-severe-covid-19-if-it-is-given-at-the-right-time/ by @elandhuis
