#Inflammasome

seth masters

sethmasters

An autoinflammatory syndrome caused by DPP9 deficiency, leading to NLRP1 inflammasome activation! Wonderful collaboration with Zhong lab and @ReversadeLab, led by @CassHarapas @KimSamirah and Kenneth Lay, with Jon Bernstein and

Prof. Akiko Iwasaki

VirusesImmunity

Several studies are coming out saying that blood LDH (lactate dehydrogenase) levels early in #COVID19 disease correlates with severe disease progression. This is a clue that #pyroptosis may be a

Stefan Bauernfried

sbauernfried

Excited to see the project I’ve been working on out on @ScienceMagazine. Thanks to @v_hornung for great guidance, as well as @ScherrMatthias from @DuderstadtLab and @PichlmairL for a wonderful collaboration.

Joanna Poole 💙

Jopo_dr

Did anyone else ever wonder why the Black Death bacteria was so effective? It has cousins that don’t really do anything exciting. Yersinia pestis has 3 key virulence factors. First

Katalin Susztak

KSusztak

Kidney disease genetic risk variants alter lysosomal beta-mannosidase (MANBA) expression and disease severity https://stm.sciencemag.org/content/13/576/eaaz1458 The study is lead by @Xiangchen_Gu @XinSheng7 and Holly Yang. Kidney function G

Prof. Akiko Iwasaki

VirusesImmunity

Very excited to share this work by the heroic team - @carolilucas Pat Wong @sneakyvirus @tiago21bio et al on “Longitudinal analyses reveal immunological misfiring in severe COVID-19”. A thread on

Ben Kamens

kamens

0/ The search for COVID-19 therapies should revolve around a single question that’s staring us right in the face, and we’re mostly ignoring it: 1/ Why are COVID-19 outcomes *dramatically*

The Professional

science_cited

1. This thread describes in detail a novel mechanism of action induced by the MMR vaccine working synergistically with aluminum adjuvant containing vaccines resulting in autoimmunity and brain damage. 2.

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