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1. This thread describes in detail a novel mechanism of action induced by the MMR vaccine working synergistically with aluminum adjuvant containing vaccines resulting in autoimmunity and brain damage.
2. In the United States children are typically given an MMR vaccine and aluminum adjuvant containing vaccines at the 12 month well-check visit. https://www.cdc.gov/vaccines/schedules/hcp/imz/child-adolescent.html
3. The CDC actually admits here that MMR vaccine does cause brain damage on rare occasions. https://www.cdc.gov/vaccines/hcp/vis/vis-statements/mmr.html
4. I propose that brain damage can occur directly from the innate immune system through a unique interaction induced by the measles component of MMR vaccine administered in combination with aluminum adjuvant containing vaccines.
5. For this interaction to occur, insoluble aluminum particles must cross the blood brain barrier. First, aluminum adjuvant nano particles found in vaccines are phagocytosed (engulfed) by white blood cells called macrophages. https://www.ncbi.nlm.nih.gov/m/pubmed/18496530
6. Inflammation within the body activates microglia (brain and spinal cells) which releases macrophage chemoattractant protein to signal macrophages across the blood brain barrier. https://www.ncbi.nlm.nih.gov/m/pubmed/19228962
7. Trapped aluminum particles can react with components of the innate immune system throughout the brain. The brain relies heavily on innate immunity and includes virtually all components of complement which are locally produced. https://www.ncbi.nlm.nih.gov/m/pubmed/21546088
8. Interestingly, studies indicate complement activation products are involved in brain development and synapse formation. https://www.ncbi.nlm.nih.gov/m/pubmed/21546088
9. During development, the formation of mature neural circuits requires the selective elimination of inappropriate synaptic connections. https://www.ncbi.nlm.nih.gov/m/pubmed/18083105
10. Mice deficient in complement protein C1q or the downstream complement protein C3 exhibit large sustained defects in CNS synapse elimination. https://www.ncbi.nlm.nih.gov/m/pubmed/18083105
11. These findings support a model in which unwanted synapses are tagged by complement for elimination and suggest that complement-mediated synapse elimination may become aberrantly reactivated in neurodegenerative disease. https://www.ncbi.nlm.nih.gov/m/pubmed/18083105
12. Complement pathways are activated by aluminum hydroxide adjuvants and result in deposition of C3 cleavage products and membrane attack complexes (MACs). https://www.ncbi.nlm.nih.gov/m/pubmed/24040248
13. A membrane attack complex will destroy the cell unless protected by a membrane-bound complement regulator. CD46 acts as a cofactor for C3b and C4b cleavage but it only protects those cells on which it is expressed. https://www.ncbi.nlm.nih.gov/m/pubmed/24161035
14. This is where measles virus comes into play. The measles virus can penetrate the blood brain barrier by a transcellular or "Trojan horse" pathway. https://www.ncbi.nlm.nih.gov/m/pubmed/29186956
15. The major measles virus receptor CD46 just happens to be the same receptor responsible for regulating complement proteins and preventing MAC formation on host cells that leads to complement-mediated cell lysis (cell death). https://www.ncbi.nlm.nih.gov/m/pubmed/1588280
16. Once inside the brain, Edmonston strain measles virus interacts with and downregulates the major measles virus receptor CD46 on uninfected cells after surface contact with infected cells. https://www.ncbi.nlm.nih.gov/m/pubmed/8523534
17. As a result of CD46 downregulation, an increased susceptibility of uninfected cells for complement-mediated lysis was observed. https://www.ncbi.nlm.nih.gov/m/pubmed/8523534
18. Due to increased susceptibility, host cells are vulnerable to complement. Interestingly, this is not advantageous for survival of the virus but rather a factor in the attenuation of infection, since it limits the spread of virus. https://www.ncbi.nlm.nih.gov/m/pubmed/8523534
19. However, over activation of complement triggered by aluminum adjuvant may lead to excessive and uncontrolled activation. Excessive and uncontrolled activation of complement proteins has been implicated in autoimmune diseases. https://www.ncbi.nlm.nih.gov/m/pubmed/28040558
20. Therefore, aluminum adjuvant combined with vaccine-strain measles virus can induce a synergistic effect on the innate immune system of the brain resulting in damaged tissue directly from complement-mediated cell lysis during excessive and uncontrolled complement activation.
