The TOPMed flagship paper of 54K whole genome sequences finally appeared in @nature. Thanks for the hard work of many TOPMed colleagues. I am honored to work with many of them. TOPMED provides a great resource to the community (1/n): A short thread https://www.nature.com/articles/s41586-021-03205-y

The TOPMed Whole Genome Sequencing data are available in dbGaP. Researchers can apply for access (2/n)

https://www.ncbi.nlm.nih.gov/gap/ 

The TOPMed variant catalog can be found at
the bravo website maintained at the University of Michigan (3/n)

https://bravo.sph.umich.edu/freeze8/hg38/ 

The multi-faceted functional annotations of the TOPMed variants can be found at http://favor.genohub.org  (4/n)

The TOPMed imputation server can be found at
…https://imputation.biodatacatalyst.nhlbi.nih.gov/# ! (5/n)

More detailed information about TOPMed can be found at https://www.nhlbiwgs.org/  (6/n)

Great thread by @gabecasis about the @nature TOPMed paper. Thanks for his, UW TOPMed Data Coordinating Center, and NHLBI, and many TOPMed investigators' leadership and contributions to the TOPMed Nature paper. https://twitter.com/gabecasis/status/1359706729219575810