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A Thread on Viral Mutations and Vaccines focusing on Covid and its variants PART1
Disclamer:
THIS IS TO HELP US UNDERSTAND THE BASICS OF MOLECULAR BIOLOGY, MUTATIONS AND VACCINATION
This for basic understanding so you might find a bit of humor..work with me ok
please RT
Disclamer:
THIS IS TO HELP US UNDERSTAND THE BASICS OF MOLECULAR BIOLOGY, MUTATIONS AND VACCINATION
This for basic understanding so you might find a bit of humor..work with me ok
please RT
Let us begin in the beginning... the real beginning 
In the beginning there was LIFE
Well an atom that gave rise to molecule that gave rise to cells; cells gave rise to tissues that gave rise to organs; organs gave rise organosystem that gave rise to..
just look at the pic
ok
In the beginning there was LIFE
Well an atom that gave rise to molecule that gave rise to cells; cells gave rise to tissues that gave rise to organs; organs gave rise organosystem that gave rise to..
just look at the pic
ok
Now Let's talk more about molecules that begin it all..
All Living organisms Have something called DNA -Deoxyribo Nucleic Acid: the building block of life .... (the stuff used in paternity test... well thats a story for another thread) let's focus
All Living organisms Have something called DNA -Deoxyribo Nucleic Acid: the building block of life .... (the stuff used in paternity test... well thats a story for another thread) let's focus
Basically DNA is the Blueprint and information to make a copy of You.... all the information of you and your family history...all found in a piece of Double stranded GCTA molecules
To make this Blueprint into a house(proteins) you need other building blocks or builders... which ever way you look at it... enter RNA...
What is that now you ask...
RNA .... Ribo Nucleic Acid ... RNA has some differences with DNA... the ribose sugar, the nucleotide U replaces T , there are 3 RNA molecules that work together to make a protein
RNA .... Ribo Nucleic Acid ... RNA has some differences with DNA... the ribose sugar, the nucleotide U replaces T , there are 3 RNA molecules that work together to make a protein
Basically the Blueprint and the builders make each brick(amino acids) that will essentially make your house...
The most important thing to take away is that in DNA the portion that we call the genetic code is only about 1% of the DNA chromosome that 1% is responsible for proteins
The most important thing to take away is that in DNA the portion that we call the genetic code is only about 1% of the DNA chromosome that 1% is responsible for proteins
RNA has 3 types
mRNA
rRNA
tRNA
mRNA
rRNA
tRNA
mRNA is made inside the nucleus from that 1% of the gene during a process called transcription, the mRNA gets a tag at the end.
mRNA strand is made up of coding areas called exons and non coding areas called introns - lets call them sense areas(exons) & nonsense areas(introns)
mRNA strand is made up of coding areas called exons and non coding areas called introns - lets call them sense areas(exons) & nonsense areas(introns)
Once transcription is done our mRNA gets a tag at the en the nonsense areas cut off by something called a splicesome - A glorified scissor complex , once the cutting off is finished it the mRNA gets to leave the nucleus for a process called translation to happen
The reason the mRNA gets so much work on it is that it doesn't get degraded in the nucleus or outside it, just like when you have important documents tagged important and confidential if not there are thrown in the bin
Transaction includes the other 2 RNA's the
2 piece suit ribosomal RNA (yes they were being very original in the naming there
)
And transfer RNA - this caries 1 amino acid on it in
2 piece suit ribosomal RNA (yes they were being very original in the naming there
)And transfer RNA - this caries 1 amino acid on it in
The mRNA attaches to the small sub unit until it reaches the start code then the 1st tRNA attaches then the big sub unit attaches then our conveyer belt start the correct tRNA brings the correct sweet to make our chain of sweets chain until it reaches a code to stop
until it reaches a code to stop
The biggest things to remember are
1 a lot of work goes to make 1 single chain of protein
2 a lot of work is done to the mRNA before it is translated to make sure less errors and the correct chain is done IN THE NUCLEUS
3 any errors from there onwards- peace nothing personal
1 a lot of work goes to make 1 single chain of protein
2 a lot of work is done to the mRNA before it is translated to make sure less errors and the correct chain is done IN THE NUCLEUS
3 any errors from there onwards- peace nothing personal
Now that we have that out the way So let's Move on to Viruses Vs Cells
Viruses are not considered living organisms because they need a host cell to hijack and make copies of itself That can happen on either a bacteria or animal/plant cell
Viruses are not considered living organisms because they need a host cell to hijack and make copies of itself That can happen on either a bacteria or animal/plant cell
So you said living things are the one that have DNA.... how come Viruses make copies of themselves in the hijacked cell? you ask....
Yeah I did here is the thing about Viruses a balled up information that are is inside a protective protein capsules.. they are 7 classes of viruses..some have DNA, others RNA, otherwise single stranded, some double stranded..reverse transcripts others positive/ negative straned
Anyway Covid falls into the IV classed single stranded, positive sensed (as if it had any sense at all to leave us alone
) RNA virus....
Polio, Rino Virus , Herpititus B and others are in the same group of delinquent.. yes I said it...
) RNA virus....Polio, Rino Virus , Herpititus B and others are in the same group of delinquent..
yes I said it...
So The reason the Virus can enter your cells is because of the crown like spikes that are able to attach to certain components on the surface of the cell ... these are locks to enter the cell and make a party in the cell by making more copies of itself
The biggest concern of Covid has been the spikes that are able to attach to your ACE2 receptors as tightly as possible to say to the cells Look i have a key let me in... and the Immune cells and anti bodies cannot come fetch the virus to go destroy it...
What does this have to do with covid?
Remember the Virus is a RNA virus... it makes its copies of itself...it by passes the DNA stage thus if mutation happens when translation occurs... peace out your going with mutations
Remember the Virus is a RNA virus... it makes its copies of itself...it by passes the DNA stage thus if mutation happens when translation occurs... peace out your going with mutations
Remember those splicesomes that cut away the nonsense parts on the mRNA they are in the nucleus& Covid-RNA doesnt get to be edited,translation occurs on it as is
its a problem because the tRNA has codes that goes in 3 nucleotides & the wrong amino acid may be placed on the chain
its a problem because the tRNA has codes that goes in 3 nucleotides & the wrong amino acid may be placed on the chain
This means there are always chances of Mutations to occur to new viruses made in the cell - we call them variants same virus just has 1 or two distortions on a certain position of the spikes
These spikes changing form will determine how tight or how loosely they bind to receptors
These spikes changing form will determine how tight or how loosely they bind to receptors
The new Covid variants that are of concern all have that very similar problem the changed form in the spikes B 1.1.7 (UK
)
B 1.351 (SA
)
all seem to become more transmissible because they (may) tightly bind with ACE2 receptors making it easy to drop the RNA into the cell
)B 1.351 (SA
)all seem to become more transmissible because they (may) tightly bind with ACE2 receptors making it easy to drop the RNA into the cell
Let me leave the lesson here for now for part 1
Part 2 will continue more on Mutations and the different between this and other normal cell mutations, and Vaccines
I'll link up videos at the end of that thread
Part 2 will continue more on Mutations and the different between this and other normal cell mutations, and Vaccines
I'll link up videos at the end of that thread
Ok let me fix a few errors that occurred during typing where you see transaction- i ment Translation
Where you saw rino its actually rhino virus herpatitis B - it's actually Hepatitis C sorry about that...
Where you saw rino its actually rhino virus herpatitis B - it's actually Hepatitis C
sorry about that...
