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4D Pharma Oncology Update 🦠

MRx0518 continues to show great promise for a blanket potential treatment across every cancer indication trailed to date, restoring the optimal function of patients immune systems in the fight against Cancer💥
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Key highlights from the update with checkpoint inhibitor KEYTRUDA®️ are as follows
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Due to the early, yet VERY significant safety/efficacy benefits initially observed in the bladder cancer cohort ⬆️

4D has quickly expanded its investigations of MRx0518 in 1st Line Maintenance Therapy in conjunction with $MRK and $PFE's Avelumab 🔥
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Presentation showing the enhanced patient benefit of Chemotherapy
followed by maintenance therapy of check point inhibitors
such as Avelumab
in Urothelial Cancer

As explained Chemotherapies do a great job in advanced cancers where...
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... the rate of growth and tumour proliferation is rife

Although check point inhibitors drastically increase survival rate (shown in this study by 31%)

Chemotherapies such as Cisplatin are known to weaken the immune system and therefore any immune response
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Couple this with the fact most people who are diagnosed with bladder cancer are over 75 years old and have pre existing weak immune systems
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Leading to a DESPERATE need for restimulation of the immune system

The need to successfully and more powerfully recruit anti cancer cells such as CD4/NK Cells to the site of the tumour once the Checkpoint Inhibitor (Avelumab) has “unveiled” the faulty cells 🧬
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“Here at 4D, we understand how the Microbiome interacts with the immune system...
We understand it better than anyone else in the world 🌏
We can stimulate the immune system to help our bodies almost naturally fight cancer”
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As previously mentioned...

🚨“The intestinal surface
(where the Microbiome resides) hosts the largest population of immune cells”🚨

Therefore the most powerful immune responses can originate from the gut💥 https://twitter.com/aimhardy/status/1347510379379908611
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