In case anyone wanted *more* evidence that kids can be important vectors of SARS-CoV-2 transmission, check out our preprint of an emergency childcare centre in Quebec led by @INSPQ with @cl_murall @SaM_bioinfo
https://osf.io/bn862/
Brief follows (1/n)
https://osf.io/bn862/
Brief follows (1/n)
This study involved traditional epidemiology and contact-tracing, along with phylogenetics that showed not one but likely *two* independent introduction events into the daycare over a couple weeks. See 'Cluster B' in the tree, separated by 4 substitutions from Cluster A:
(2/n)
(2/n)
Key finding: we infer transmission events from kid-to-adult, adult-to-kid, and kid-to-kid. Kids are mostly asymptomatic. (3/n)
Another tidbit: mothers suffer higher attack rates than fathers. Maybe because they tend to be primary caregivers? (4/n)
This was considered a big outbreak, but of course a relatively small sample of overall infections. Still, we can infer transmission events with quite good confidence with combined contact tracing and sequencing + phylogenetics, enabled by the http://covseq.ca team. FIN