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1) CRITICAL!!: The entirety of COVID-19 is cholinergic. Children have less severe cases overall as their cerebral cortex has not developed AChE-reactive cholinoceptive pyramidal neurons. They are less likely to suffer from the neurologically induced cardiopulmonary failure
2) seen with increasing frequency as age ascends. The AChE-rich histochemical pattern in these neurons appears to be absent in childhood, emerges during adolescence, and seems to increase in intensity in adulthood and old age. The physiological significance of this developmental
3) change is unknown but suggests the presence of age-related changes in the way in which the cerebral cortex reacts to ACh. This group of AChE-rich pyramidal neurons is much less conspicuous in monkey and rat brains. THIS IS WHY MONKEY AND RAT STUDIES ARE MEANINGLESS!
4) The acetylcholine receptors of the Nucleus Basalis of Myenert are toxified during the acute phase and destroyed in a possible autoimmune sequela. Schizophrenic patients already have deteriorated NBMs. This is why, after age, they are most at risk. The dysfunction of the NBM is
5) causing a neurovascular uncoupling resulting in inadequate blood supply of active neurons. This leads to encephalopathy and neuronal death. This is why early treatment is vital. At a certain point, the patient is neurologically terminal. https://www.oruen.com/psychiatry/schizophrenia/neuropathological-changes-in-the-nucleus-basalis-in-schizophrenia
