Read on Twitter
This is an interesting #LongCOVID theory - that there is persistent brainstem dysfunction (likely in tangent with other immune issues like immune dysregulation, reactivation of other viruses, onset of autoimmune conditions).
A thread including some new & important papers: 1/
A thread including some new & important papers: 1/
"Persistent Brainstem Dysfunction in #LongCOVID: A Hypothesis." Would be very curious to hear researchers' thoughts on this one! 2/ https://pubs.acs.org/doi/10.1021/acschemneuro.0c00793
Hypometabolism found in brain PET scans in #LongCOVID patients! https://link.springer.com/article/10.1007/s00259-021-05215-4
Results: a decrease in brain activity in:
-olfactory bulb
-limbic regions: memory/emotion regulation
-brainstem: autonomic functions (breathing/sleeping)
-cerebellum: motor skills/balance 3/
Results: a decrease in brain activity in:
-olfactory bulb
-limbic regions: memory/emotion regulation
-brainstem: autonomic functions (breathing/sleeping)
-cerebellum: motor skills/balance 3/
Paraphrasing: this is huge deal & provides objective confirmation for #LongCOVID patients. MRIs are normal, but hypometabolism is found in PET scans w' 100% classification ability to separate patients & controls. Also: symptom severity correlates w' metabolic PET severity 4/
Also find this curious bc some of the top symptoms we found in our #LongCOVID paper include changes to smell & taste, memory issues, cognitive function issues, sleep disorders, sensorimotor symptoms (esp dizziness & vertigo), breathing issues even without pulmonary issues 5/
Here is a layman's version of the #LongCOVID brain hypometabolism study (there's a decent translation in English using the google translate button)
http://fr.ap-hm.fr/actu/covid-long-le-vecu-des-patients-corrobore-par-l-imagerie-cerebrale 6/
http://fr.ap-hm.fr/actu/covid-long-le-vecu-des-patients-corrobore-par-l-imagerie-cerebrale 6/
