This study showed that among young adults the incidence rates of heart failure were approximately 6-fold higher among those at the highest quartile of serum uric acid (>6.3 mg/dL) compared with those at the lowest quartile (<3.4 mg/dL). https://pubmed.ncbi.nlm.nih.gov/19919980/ 
As fluoride increases serum uric acid levels and is linked directly to hyperuricemia, these findings strongly suggest that adolescents with higher exposure fluoride are more prone to development of pathologies associated with hyperuricemia in later years including heart failure.
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