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1/13 COVID-19 had a significant impact on our research activity but our researchers adapted brilliantly and work @CRUK_BI continued to thrive. This #WorldCancerDay 
#WCD2021 , we're highlighting just some of the successes from the past year:
#WCD2021 , we're highlighting just some of the successes from the past year:
2/13 We're incredibly proud of our scientists who volunteered their time, day and night, to work in the Glasgow @LhouseLabsUk testing for COVID-19. Well done, everyone! #WCD2021
3/13 With some sadness, we 'virtually' waved goodbye to a fantastic cohort of students after successful PhD defences - but also welcomed 12 new PhD students and CRTFs to the team who adapted superbly to the current situation. #WCD2021
4/13 In October, we congratulated @owen_sansom on his new leadership role as Director of the MRC National Mouse Genetics Network – an outstanding new initiative for human disease modelling, working towards new, effective diagnosis and therapy. #WCD2021
https://mrc.ukri.org/news/blog/national-mouse-genetics-network/
https://mrc.ukri.org/news/blog/national-mouse-genetics-network/
5/13 @RossCagan and @Drjohnlequesne joined us with great enthusiasm and expertise to start new groups @CRUK_BI @UofGCancerSci. Together, we're excited to engage in work on personalised cancer therapeutics and deep phenotyping of tumours. #WCD2021
6/13 Huge congratulations to the following on gaining major funding: 
@robinsall – Wellcome Trust Award, @DavidBryantLab and @JbirchJ – UKRI Future Leaders Fellowships #wcd2021
@robinsall – Wellcome Trust Award, @DavidBryantLab and @JbirchJ – UKRI Future Leaders Fellowships #wcd2021
7/13 
With colleagues around the world, @CRUK_BI published over 120 papers in our key research areas - cancer metabolism, tumour microenvironment and metastasis. Here are some of the highlights:
#worldcancerday2021 #wcd2021
With colleagues around the world, @CRUK_BI published over 120 papers in our key research areas - cancer metabolism, tumour microenvironment and metastasis. Here are some of the highlights:#worldcancerday2021
#wcd2021
8/13 Using structural biology approaches, @chatrin_ch & @maxgabro et al. identified novel targets that could be inhibited through protein turnover. They described a mechanism where ubiquitin itself is a target for post-translational modification. #WCD2021 https://advances.sciencemag.org/content/6/38/eabc0418
https://advances.sciencemag.org/content/6/38/eabc0418
9/13 @Nathi_Muthalagu et al. described novel mechanisms of how pancreatic tumours evade Natural Killer cells. This involves the suppression of the type I IFN pathway by mutant KRAS and deregulated MYC. #WCD2021 https://cancerdiscovery.aacrjournals.org/content/10/6/872
https://cancerdiscovery.aacrjournals.org/content/10/6/872
10/13 @RafaPhD et al. now have new strategies for targeting protein synthesis in KRAS-mutant colon cancer. The team showed that SLC7A5, a glutamine transporter, is crucial for tumourigenesis in models of early and late stage metastatic disease. #WCD2021 https://www.nature.com/articles/s41588-020-00753-3
https://www.nature.com/articles/s41588-020-00753-3
11/13 @vassilis_p et al. identified metabolic determinants for pancreatic cancer metastasis. They used metabolomics to reveal that the creatine-phosphagen ATP-recycling system is a major mechanosensitive target. #WCD2021 https://www.nature.com/articles/s42255-019-0159-z
https://www.nature.com/articles/s42255-019-0159-z
12/13 Interlinking the biology of early disease with energetic stress, Smith et al. showed that mitochondrial mutations are associated with tumour initiation in colorectal cancer and may induce a targetable state. #WCD2021 https://doi.org/10.1038/s43018-020-00112-5
https://doi.org/10.1038/s43018-020-00112-5
13/13 @LukeTweedy1 et al. modelled a cell migration mechanism, conserved from slime mould to pancreatic cancer cells; cells navigate complex environments like man-made mazes by following and leaving chemical 'crumbs', rapidly finding the shortest path. https://science.sciencemag.org/content/369/6507/eaay9792
