Something that hasn't really been discussed in relation to the 2001 organizing resolution is the provision for discharging bills/nominations that received tied votes in committee.
It remains to be seen whether 1) committees this Congress will be tied (I assume they will be) and 2) whether this discharge provision will be included in the organizing resolution, or if Schumer/McConnell will treat a tie vote as a majority vote to report.
This will make judicial confirmations take up more time. E.g. if the Judiciary Committee deadlocks on reporting nominees w/o blue slips, then the Senate has to burn up to 4 hours on a discharge motion, which VP Harris has to break a tie on, and then 30 more hours post-cloture.
Dems have one advantage, at least for district judges, that Rs didn't in 2017. The post-cloture time reform that McConnell went nuclear on in 2019 is still valid, so district judges only have 2 hours of post-cloture debate time.
More information: https://www.everycrsreport.com/reports/RS20785.html