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This is a good high level discussion on variants and immune responses & importantly also faces head on the possibility that some people are injured or even killed by vaccines to SARS-COV-2, while being clear that it’s completely unreasonable to associate all deaths which occur...
... shortly after vaccination are in any way caused by them. https://medicalxpress.com/news/2021-01-vaccine-wars-escalate-antibody-variants.html
Regrettably, people die, some of them due to this virus & some despite having recently been administered a vaccine.
An important caveat to the - in my view, excessive - concern about “immune escape” from vaccine based immunity is that it solely applies to (1) antibody...
An important caveat to the - in my view, excessive - concern about “immune escape” from vaccine based immunity is that it solely applies to (1) antibody...
... responses & ignores T-cell immune responses which are more catholic and (2) the whole discussion ignores that natural immunity is doubtless a key part - possibly the more important part - of population immunity to the virus. In (2) it’s as near as dammit certain that, at...
... the slow rate of mutation which characterises changes in SARS-COV-2, immune escape from natural immunity isn’t ever going to happen.
Even those protected only by vaccines, protection which might reduce, if changes to the spike protein lead to variants to which one part...
Even those protected only by vaccines, protection which might reduce, if changes to the spike protein lead to variants to which one part...
... of the immune response, the polyclonal antibody response, is somewhat reduced, the person isn’t going to left catastrophically unprotected. Even in the reasonable worst case, other polyclonal antibody component responses to vaccination will continue to provide some...
... protection as will T-cell immunity.
Even spike alone is a very big protein (1273 amino acids). Variants are numerically conservative in that the vast majority of the protein is unchanged despite them & immune responses to various portions of spike will also be conserved.
Even spike alone is a very big protein (1273 amino acids). Variants are numerically conservative in that the vast majority of the protein is unchanged despite them & immune responses to various portions of spike will also be conserved.
But the really encouraging thought is that natural immunity to spike variants & to non-spike portions of the virus will still be generated in vaccinated individuals exposed for the first time to whole virus. Vaccines will have done their job, even if mutant-based immune escape...
... from fragments of the immune response to vaccines do occur, because it won’t be all or none.
We are not going to see a sudden wave of new variant terror, for all the reasons above. Multiple vaccines, varying & polyclonal antibody responses to several epitopes within...
We are not going to see a sudden wave of new variant terror, for all the reasons above. Multiple vaccines, varying & polyclonal antibody responses to several epitopes within...
... spike, protective T-cell responses to spike & the background population protein from immunity developed to whole virus will together ensure that doesn’t happen.
