French study, published in 2018, found that more than 1/2 of early onset dementia cases comprised people with alcohol-related brain damage or alcohol use disorders.

https://www.thelancet.com/journals/lanpub/article/PIIS2468-2667(18)30022-7/fulltext
I might start putting interesting studies about the risks of alcohol use/abuse in one thread rather than scattered all about the place.
Australian study from last year.

‘Alcohol consumption confers a significant risk of cancer, and drinking pattern may be independently related to breast cancer risk.’ https://www.nature.com/articles/s41416-020-01101-2
‘Increasing levels of alcohol intake were associated with increased risk of cancers of the upper aerodigestive tract, mouth and pharynx, oesophagus, colorectum, colon, liver & breast.’
‘Breast cancer risk was marginally associated with drinking pattern, with higher risk when intake was concentrated on 1–3 days/week compared to the same amount spread over 4–7 days.’
‘Alcohol consumption is an important risk factor for cancer and has been estimated to account for 2.8% of cancers in Australia and 5.5% of cancers globally, as well as 4.5% of the cancer burden in Australia.’
‘Studies first identified a relationship between alcohol and cancer as far back as 1903.’
‘& in 1988, the International Agency for Research on Cancer classified alcohol as a Group 1 carcinogen (the highest IARC classification) for cancers of the mouth, pharynx, larynx, oesophagus and liver.’
‘In 2010–2012, IARC reviewed the evidence and determined that there is a causal relationship between alcohol and colorectal and female breast cancer.’
‘In our study, the relative risk of incident cancers known to be caused by alcohol increased by 10% with every additional seven drinks per week’
‘with consumption of more than 14 drinks a week estimated to account for a 4.4% higher absolute cumulative risk in men compared to consumption of 0 to <1 drink per week (i.e., 17.3% vs. 12.9%), and 5.4% higher risk in women (i.e., 25.0% vs. 19.6%), up to age 85 years.’
Posted this yesterday, might as well put it in this thread https://twitter.com/post_liberal/status/1355522357239156744?s=20
Might as well throw this into the thread too https://twitter.com/post_liberal/status/1354703418095501312?s=20
& also this mini-thread about the alcohol sales bans in South Africa during the current pandemic https://twitter.com/post_liberal/status/1355066511023607808?s=20
& this too https://twitter.com/post_liberal/status/1355179096200929280?s=20
‘Alcohol is an established major cancer risk factor that contributes considerably to the burden of disease and death world‐wide. For Europe, it has been estimated that almost one in three alcohol‐attributable deaths were due to cancer’
‘To the current state of knowledge, the intake of alcoholic beverages is causally linked to an increased risk for cancer of the oral cavity, pharynx, esophagus (squamous cell carcinoma), colorectum, liver, larynx and breast (post‐menopausal women.)’
‘Even low levels of alcohol use below established drinking guidelines are associated with a statistically increased cancer risk; however, the greatest risk increases are observed for heavy, long‐term alcohol consumption’
‘In Germany, an estimated 2.2% of all cancer cases in 2018 were attributable to high alcohol consumption. Despite a slight reduction in the prevalence of alcohol use over recent decades.......’
‘........ Germany is still ranked among countries with the highest intake of alcohol in the World Health Organization (WHO) European region which, in turn, is the region with the highest alcohol intake world‐wide.’
‘During the 30‐year study period, an estimated 10.1% of alcohol‐related cancer cases in men and 1.4% in women could be avoided if the total population were to adhere to lower drinking guidelines.’
‘Accordingly, the future burden of alcohol‐related cancer cases could be reduced by approximately 200 000 cancer cases in men and 44 000 cases in women.’
‘The article, which appears in Cancer Epidemiology, states that the proportion of cancer cases attributable to alcohol consumption ranged from......’
‘.......... a high of 6.7% in Delaware to a low of 2.9% in Utah. Similarly, Delaware had the highest proportion of alcohol-related cancer deaths (4.5%) and Utah had the lowest (1.9%).‘
‘The proportion of alcohol-related cancers was far greater for some individual cancer types. For oral cavity/pharyngeal cancer cases, for example, it ranged from 36% in Utah to 62.5% in Delaware and was 45% or more in 45 states and the District of Columbia.’
‘By sex, alcohol-related cancer cases and deaths for most evaluated cancer types were higher among men, in part reflecting higher levels of alcohol consumption among men.’
‘In the U.S. on average, alcohol consumption accounted for 4.8% of cancer cases and 3.2% of cancer deaths, or about 75,200 cancer cases and 18,950 cancer deaths annually, during 2013 to 2016.’
‘English-speaking countries & Scandinavia get drunk more times per year than in any other country.’

1. 🏮󠁧󠁱󠁳󠁣󠁮󠁿
2. đŸŽó §ó ąó „ó źó §ó ż
3. 🇩đŸ‡ș
4. đŸ‡©đŸ‡°
5. đŸ‡«đŸ‡ź
6. đŸ‡ș🇾
7. 🇹🇩
8. 🇹🇼
9. đŸ‡«đŸ‡·
10. đŸ‡§đŸ‡·

https://www.globaldrugsurvey.com/wp-content/uploads/2021/01/GDS2020-Executive-Summary.pdf
‘Participants from English-speaking countries and Scandinavia reported getting drunk most often (🇬🇧
34 times in last year, 🇩đŸ‡ș/đŸ‡©đŸ‡° 32, đŸ‡«đŸ‡ź 28), while participants from South American
countries reported the lowest number of occasions (đŸ‡ŠđŸ‡· and 🇹🇮 less than 7 times).’
🇾đŸ‡Ș banned the sale of alcohol in all nightclubs after 10 pm, starting on 20 November. 🇾đŸ‡Ș Police report a reduction in violent crime subsequently.

‘A logical consequence of the fact that we do not have as many drunk people in limited geographical areas.’ https://accentmagasin.se/alkohol/polisen-farre-valdsbrott-med-alkoholstopp/
.............. https://twitter.com/ActiveBuildings/status/1346067156639866880?s=20
............... https://twitter.com/ONS/status/1356545127125237762?s=20
................. https://twitter.com/ian_hamilton_/status/1356611482809741314?s=20
Alcohol-related death-rates higher in the North of England than in the Midlands & the South
‘Around four in every five deaths were caused from alcoholic liver disease.’
2019 alcohol stats from the ONS.

- Highest alcohol death-rate in NI.
- Male alcohol death-rate twice as high as the female one.
- Death rates higher amongst people aged between 55-64 than any other age.
- Alcohol-specific death-rates up 11.3% since 2001.

https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/causesofdeath/bulletins/alcoholrelateddeathsintheunitedkingdom/registeredin2019
Interesting couple of paragraphs about Scotland who have introduced minimum unit pricing
& Figure 6 in the ONS publication shows that: ‘Scotland is the only country to see a decrease over time in female rates of alcohol-specific deaths.’
Not a surprise that the biggest decrease in alcohol consumption during this pandemic has been in 🇿🇩 (see up thread)

https://www.ipsos.com/en-nl/covid-diet-and-health
4 out of the top 5 countries who have increased their levels of alcohol consumption during this pandemic the most are English-speaking, namely:- 🇩đŸ‡șđŸ‡ș🇾🇹🇩 & 🇬🇧.
By banning the sale of alcohol, on more than one occasion during this pandemic, 🇿🇩 managed to reduce their levels of alcohol consumption by 24%.
Good thread on the ONS alcohol stats https://twitter.com/InstAlcStud/status/1356550490117529600?s=20
Lockdown sceptics will, no doubt, use this to buttress their case against lockdowns but the bulk of these deaths are from alcohol liver disease. You don't get ALD from one year of drinking but from many years. Its that sub-group who we need to focus on. https://twitter.com/bmj_latest/status/1356959909255008259?s=20
ONS report says 77.2% of the deaths from alcohol that were recorded were related to alcoholic liver disease. You dont get ALD from one year of drinking so we are talking about a group who were high-risk BEFORE lockdowns. This isn't an issue that can be reduced solely to lockdowns
............. https://twitter.com/EUROCAREBRUSSEL/status/1357370842431303680?s=20
................ https://twitter.com/PeteSarich/status/1356769189462036481?s=20
‘Estimates suggest that over 5 years the National Health Service (NHS) will incur £17 billion in costs related to alcohol misuse.’
Merchants of doubt https://twitter.com/julia_stafford1/status/1339365860268335105?s=20
‘Studies have also highlighted relationship between outlet density & other traffic-related consequences...drinking-driving & riding with intoxicated drivers, alcohol-involved pedestrian collisions, traffic injury rates requiring hospitalisation & alcohol-related crash fatalities’
The Cannabis industry will go exactly the same way. The preponderance of Cannabis outlets will be in poorer areas, rich people wont want them where they live, oh no, you watch & see.
‘The relationship between alcohol & mental health is also bidirectional.’

Well, ofc, this applies to Cannabis use too, i.e ppl with MH probs are more likely to abuse drugs/alcohol but also, ppl who abuse drugs/alcohol are more likely to develop MH problems.
‘Each additional liquor store in the neighbourhood was associated with an increase by 1% in the mean number of standard drinks of alcohol consumed per drinking day and by 6% in the mean number of days of harmful consumption of alcohol.’
‘We observed that the odds of hospital contact for anxiety, stress or depression was 56% greater among participants with a liquor store within the neighbourhood compared to those without.’
In conclusion:-

‘Participants with greater access to liquor stores were more likely to consume alcohol at harmful levels and to have had a hospital contact for anxiety, stress or depression.’

Not rocket science is it?
Pretty impressive
‘The study found the rate of trauma-related admissions, such as injuries sustained in a car accident and personal injuries and violence, were more than halved, from 10.5 per cent of total ICU admissions to less than 5 per cent.’
‘The introduction of the Alcohol Act in Scotland in 2011 was associated with a decrease in total off‐trade alcohol sales in Scotland, largely driven by reduced off‐trade wine sales.’

https://onlinelibrary.wiley.com/doi/full/10.1111/add.12701
New book looks at why violent crime has reduced so much in 🇩đŸ‡ș after increasing thru’ the 1970s-90s - the overall homicide rate fell by 59% in the first 2 decades of the 21stC! - & links this to (amongst other things) reduced alcohol use amongst young ppl

https://www.smh.com.au/business/the-economy/it-s-time-to-salute-the-great-crime-decline-20210202-p56ynw.html
‘New findings published this week show that 🇩đŸ‡ș‘s continue to top charts and set global records when it comes to drinking...🇩đŸ‡ș‘s who drink alcohol got drunk an average of x32 over 12 months, with the global average being just 21.’
‘Interestingly, Australians were also the least likely in the world to regret getting drunk, regretting only 27% of the times we got drunk.’
‘Young Australian women, however, were twice as likely as the global average to seek medical treatment after drinking. “Australia is second to Russia,” Barratt explains, “as the highest proportion of people seeking medical treatment following drinking.”’
More about the alcohol industry’s role as ‘merchants of doubt,’ this time in Western Australia

https://onlinelibrary.wiley.com/doi/full/10.1111/dar.13147
The wine-drinking countries of đŸ‡«đŸ‡·&🇼đŸ‡č reduced their levels of alcohol consumption by more than half, whilst the beer-drinking countries of đŸ‡©đŸ‡Ș🇬🇧& 🇩đŸ‡ș nearly doubled their levels of consumption in the case of 🇬🇧 & more than doubled in the case of 🇩đŸ‡ș & đŸ‡©đŸ‡Ș, during the period 1920-2014
In 1939 the average French person drank more half a bottle of wine a day apparently & as recently as 1961 the average French person was drinking the equivalent of 25 glasses of wine a week

https://www.ft.com/content/3f48912c-4831-11ea-aeb3-955839e06441
Which seems like a lot to me!

Interesting to note that the suicide-rate for French men was 17.9 per 100k in 2016 but a mere 30 years earlier it had been nearly double that, 33.1 per 100k in 1985.

That might be a coincidence but I suspect not.

https://en.wikipedia.org/wiki/Suicide_in_France
‘From 1913 to 1916, the average annual suicide rate was 15.4 per 100,000. However, after Prohibition went into effect, the average annual suicide rate fell 22%, to 12.0 per 100,000.”’ https://www.psychologytoday.com/us/blog/acquainted-the-night/202003/how-lower-the-suicide-rate
........... https://twitter.com/oldagepsych/status/1345679023062581248?s=20
.............. https://twitter.com/oldagepsych/status/1346786508569767936?s=20
............. https://twitter.com/oldagepsych/status/1347481487608864768?s=20
.............. https://twitter.com/oldagepsych/status/1347954965478780929?s=20
........... https://twitter.com/oldagepsych/status/1352537505661259778?s=20
.................. https://twitter.com/oldagepsych/status/1352906571832033280?s=20
................. https://twitter.com/oldagepsych/status/1355051871786954758?s=20
........... https://twitter.com/KulikovUNIATF/status/1352351142475407368?s=20
.............. https://twitter.com/PeteSarich/status/1339050431557693440?s=20
‘There are more deaths every year from alcohol than in the entire opioid epidemic,” notes Keith Humphreys, a professor of psychiatry at Stanford....& even though alcohol is legal, it “accounts for more crime than all the drugs put together”’

https://s3.amazonaws.com/external_clips/3627587/046-051_Addiction_Alcohol_SHIP.pdf?1606757364
‘Although heavy drinking is still largely a male problem, women are drinking more in đŸ‡ș🇾.... women are more sensitive to alcohol and its related cancers.... The number of yearly alcohol-related deaths doubled between 1999-2017, according to an analysis of death certificates’
I feel sorry for the people of Baltimore, whenever you hear about the city its never good news
🇬🇧: ‘government estimates found that 39 percent of violent crime is committed under the influence.’

đŸ‡ș🇾: ‘some 40 percent
of people incarcerated for violent crimes had been drinking during the offence.’
............... https://twitter.com/dianovaportugal/status/1356926213948850178?s=20
Note the Kit Malthouse quote in this letter stating that nearly 40% of violent crime in this country involves a perp under the influence of alcohol https://twitter.com/keithnhumphreys/status/1263475899724333056?s=21
The only surprise from my perspective is that its not higher than that.

‘Acute alcohol use is associated with repeated self‐harm and completed suicide... alcohol use is overwhelmingly the most common substance used in association with suicidal crisis‘

Aye, you’re not kidding.
‘Previous research indicates that acute alcohol use increases risk of suicide irrespective of alcohol use disorder.’

*Irrespective of alcohol use disorder.*

Important to emphasise bc many fail to grasp that the relationship between alcohol & self-harm/suicide is bidirectional.
i.e the relationship between alcohol & MH probs/self-harm/suicide isnt just one way, it runs in both directions.
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