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An underlying cause, or effect, or both, of aging, is inflammation.
This is so characteristic of aging that it's been dubbed "inflammaging".
This is so characteristic of aging that it's been dubbed "inflammaging".
Where does the inflammation come from?
Could be from "garb-aging", the presence of molecular garbage, or from bacterial LPS. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0097171
Could be from "garb-aging", the presence of molecular garbage, or from bacterial LPS. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0097171
Inflammation in general is mediated by prostaglandins in turn derived from arachidonic acid.
Resolvins, which dampen inflammation, are made from omega-3 fatty acids.
Resolvins, which dampen inflammation, are made from omega-3 fatty acids.
Inflammation also activates mTOR, a key molecular component involved in aging.
Deactivating mTOR increases lifespan.
Blocking inflammatory cytokines also deactivates mTOR.
https://www.jci.org/articles/view/43873
Deactivating mTOR increases lifespan.
Blocking inflammatory cytokines also deactivates mTOR.
https://www.jci.org/articles/view/43873
In turn, deactivating mTOR with rapamycin decreases inflammation.
https://www.ahajournals.org/doi/full/10.1161/CIRCRESAHA.119.315185
https://www.ahajournals.org/doi/full/10.1161/CIRCRESAHA.119.315185
All of this suggests the following:
*omega-3 fatty acids (from fish and fish oil) can decrease inflammaging
*rapamycin may work to extend lifespan via decreased inflammation
*omega-3 fatty acids (from fish and fish oil) can decrease inflammaging
*rapamycin may work to extend lifespan via decreased inflammation
and perhaps most relevant
*fasting, exercise, healthy diet, and good body composition make for a resilient, non-inflammatory physiology that promotes long life and good health.
*fasting, exercise, healthy diet, and good body composition make for a resilient, non-inflammatory physiology that promotes long life and good health.
