Read on Twitter
1/ Key question right now is how much SARS-CoV-2 vaccines will decrease transmission.
Data from Regeneron mAb cocktail prevention press release may help us think about this https://investor.regeneron.com/news-releases/news-release-details/regeneron-reports-positive-interim-data-regen-covtm-antibody
Data from Regeneron mAb cocktail prevention press release may help us think about this https://investor.regeneron.com/news-releases/news-release-details/regeneron-reports-positive-interim-data-regen-covtm-antibody
2/ They report their mAb cocktail had 100% efficacy in preventing symptomatic COVID-19 (8/223 placebo vs. 0/186 REGEN-COV)
They also report lower ASYMPTOMATIC infection (15/223 placebo vs. 10/186 REGEN-COV)
They also report lower ASYMPTOMATIC infection (15/223 placebo vs. 10/186 REGEN-COV)
3/ Among the infections, way less peak viral load and viral shedding seen
- Avg peak VL >100x placebo vs REGEN-CoV
- Infections in REGEN-CoV lasted <1 week, while 40% in placebo lasted 3-4 weeks
(would be nice to see VL comparison just for asymptomatic cohorts)
- Avg peak VL >100x placebo vs REGEN-CoV
- Infections in REGEN-CoV lasted <1 week, while 40% in placebo lasted 3-4 weeks
(would be nice to see VL comparison just for asymptomatic cohorts)
4/ So overall: mAb for prevention prevented symptomatic infection & had lower asymptomatic infection. Peak VL much lower in mAb with less shedding.
We might expect similar protections and findings for vaccinated people.
We might expect similar protections and findings for vaccinated people.
5/ As @AaronRichterman has beautifully summarized, there is accumulating strong evidence that asymptomatic infection is associated with much less transmission risk https://twitter.com/AaronRichterman/status/1351548860968013828?s=20
6/ We need more data, but this report is consistent with the unfolding story
Lots of reason to think that the vaccines will massively decrease transmission (not just symptomatic infection)
For now we must continue to mask, distance, etc, but a good time to be hopeful
Lots of reason to think that the vaccines will massively decrease transmission (not just symptomatic infection)
For now we must continue to mask, distance, etc, but a good time to be hopeful
