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I'm beggining to wonder if anyone actually understands retrocausality because this is about as close as you get to it.
We can't play catch up like this. We have to be several steps ahead. Vaccines targeting the Spike Proteins will only encourage mutations and future variants. https://twitter.com/cathynewman/status/1353393831782322177
We can't play catch up like this. We have to be several steps ahead. Vaccines targeting the Spike Proteins will only encourage mutations and future variants. https://twitter.com/cathynewman/status/1353393831782322177
We have already seen vaccine escape variants emerge more frequently in regions where vaccine trials took place. This may be coincidence but if so it's a big one. I believe Andrew Pollard has stated it's unlikely because of the low numbers of people in the trials.
Yet B.1.1.7 supposedly emerged in a single immunocompromised patient in a hospital in Kent. It only takes one infected patient to cause a mutation leading to an escape variant. E484K causes me particular concern. It has developed independantly in South Africa and Brazil.
And this week we believe E484K has again arisen independantly, probably in a single patient in Liverpool.
In a way we are lucky since all three escape variants are mutations of the same type so it is easy to adjust the vaccine to deal with it.
In a way we are lucky since all three escape variants are mutations of the same type so it is easy to adjust the vaccine to deal with it.
However this will take months and once implemented simply encourage another mutation elsewhere on the spike.
We know spike proteins mutate frequently. We have patted ourselves on the back by creating the simplest solution we could find.
We know spike proteins mutate frequently. We have patted ourselves on the back by creating the simplest solution we could find.
But it simply is not going to provide us with a long term stable and sustainable solution. The virus mutates too frequently and we quite simply cannot genome sequence quickly enough across the globe to compensate for it.
We will never be able to find solutions to problems we are not aware of
I'd suggest the way forward is to put all our resource into developing a vaccine that targets the internal viral proteins which mutate far less frequently & whose mutations are less likely to be escape type
I'd suggest the way forward is to put all our resource into developing a vaccine that targets the internal viral proteins which mutate far less frequently & whose mutations are less likely to be escape type
Incidentally Bonnies Bloom above you have not a cat in hells chance of doing this within the next decade
LOOK AT WHAT IS HAPPENING
We are seeing comfortably over a dozen mutations per variant. We don't have a glue what each means until we see the results on the ground. We cannot keep up.
https://mobile.twitter.com/RNajmanovich/status/1351257989311827970
@firefoxx66 @nextstrain
We are seeing comfortably over a dozen mutations per variant. We don't have a glue what each means until we see the results on the ground. We cannot keep up.
https://mobile.twitter.com/RNajmanovich/status/1351257989311827970
@firefoxx66 @nextstrain
