#QuantitativeAndRigorousPS papers created in response to pings asking that I list papers that represent "quantitative & rigorous work" in the field of intracellular phase transitions. I indicated there were numerous, but challenge seen, challenge accepted

Set up constraints for myself. No more than 15 papers to be listed, published 2018-2020, integrates multiple length scales or methods, steer clear of transcription & chromatin, & no more than 3 in the #humblebrag category. My list coming up, hope others follow suit

My list begins here, starting with three papers focused on stress granules
https://doi.org/10.1016/j.cell.2020.03.050, @DavidWSanders2, @brangwynnelab
https://doi.org/10.1016/j.cell.2020.03.046
https://doi.org/10.1016/j.cell.2020.03.049 (this is 1 out of 3 in the #humblebrag category) @titus_franzmann, @alexholehouse
https://doi.org/10.1016/j.cell.2020.03.050, @DavidWSanders2, @brangwynnelab
https://doi.org/10.1016/j.cell.2020.03.046
https://doi.org/10.1016/j.cell.2020.03.049 (this is 1 out of 3 in the #humblebrag category) @titus_franzmann, @alexholehouse
Molecular grammar underlying phase separation of FUS /FET family proteins - from our collaboration with Simon Alberti and @HymanLab (2 out of 3 in #humblebrag category) https://doi.org/10.1016/j.cell.2018.06.006
Is fixed saturation concentration to be expected when there is an interplay of homotypic and heterotypic interactions?
https://www.nature.com/articles/s41586-020-2256-2
@SuperSciJew, @brangwynnelab, @kriwacki
Also, there is a paper of ours ( @FarquadDar ), but I stick to the moratorium I imposed
https://www.nature.com/articles/s41586-020-2256-2
@SuperSciJew, @brangwynnelab, @kriwacki
Also, there is a paper of ours ( @FarquadDar ), but I stick to the moratorium I imposed

https://science.sciencemag.org/content/367/6478/694
(3 out of 3 in the #humblebrag category), collaboration with my good friends @TanjaMittag, @ewmartin, & the one and only @alexholehouse
(3 out of 3 in the #humblebrag category), collaboration with my good friends @TanjaMittag, @ewmartin, & the one and only @alexholehouse
A must read from @BanerjeeLab_UB - reveals a range of complexities that are accessible in bottom-up reconstitutions. In a word, this is brilliant! https://www.pnas.org/content/117/27/15650.short
Super important paper; you see sub-µm clusters, does this mean the underlying phenomenon is governed by phase transitions? What constraints are operative? From @IbrahimCisse_ https://elifesciences.org/articles/39695
Putting the tenets of equilibrium phase separation to rigorous tests from Mike Rosen https://elifesciences.org/articles/56525
Amy's always in my ears about RNA & hence not to be forgotten - RNA, RNA structure and its impact on fungal RNPs from @GladfelterLab https://science.sciencemag.org/content/360/6391/922.abstract
RNP granules aren't just about proteins; the buffering role of RNA highlighted beautifully in this work by the @HymanLab and Alberti labs https://science.sciencemag.org/content/360/6391/918/tab-article-info
The general concept is phase separation (not just LLPS) with no constraints on what the coexisting phases ought to be - beautiful work from Andrea Putnam & Geraldine Seydoux https://www.nature.com/articles/s41594-019-0193-2
Absolute jaw-dropping read from @ShorterLab https://doi.org/10.1016/j.cell.2018.03.002
Although not spelled out as such, the tenets of polyphasic linkage (shout out to @FarquadDar and Kiersten Ruff), i.e., ligand-mediated regulation of phase behavior is highlighted in this beautiful paper from Rosen & Chook https://doi.org/10.1016/j.cell.2018.03.003
Phosphorylation dependent phase separation of FMRP and CAPRIN1 - from Julie Forman-Kay - this is a real beauty!!! https://science.sciencemag.org/content/365/6455/825/tab-article-info
That is my list of 15 staying staying within constraints I imposed on myself. So many more that belong to #QuantitativeAndRigorousPS. Hoping other mates will contribute. Tagging: @brangwynnelab, @HymanLab, @TanjaMittag, @ShorterLab, @DormannL, @lucaspelkmans, @alexholehouse
Tagging more savants: @DavidWSanders2, @SuperSciJew, @YSPTSPS, @SchmitBiophys, @GladfelterLab, @LeeBioPhysics, @BioCondensates, @idpsig, @weber_lab, @bsabari, @LabPetry, @titus_franzmann, @Ji_young_Youn, @IbrahimCisse_, et al., share your favs in #QuantitativeAndRigorousPS papers
Also, @dallandrummond, @SElbaumG, @WebersGroup, @LabStrader, @Pha_Tran_Papers, @rcollepardo, @KnowlesLabCamb, @seresanu, @schmidt_lab, @omc111, @zechnerlab, @youngricka
How on earth did I forget to tag @Castaneda_lab
