One last tweet for today...
But I don't think the conceptualization risk-benefit with vaccines has ever been stated more clearly than by Ben Franklin. He had a son (Franky Franklin) who died of smallpox. They didn't have "vaccines" yet but they had a kind of pre-vaccine...

"Inoculation", where people got smallpox pus from a pustule rubbed into a scratch in their arm (or sometimes took ground smallpox scabs as a snuff). It worked.

But had an unfavorable "adverse event profile":

1. You could get regular smallpox from inoculation

2. Or you could start a smallpox epidemic in a place that had no smallpox. (That's why George Washington held off vaccinating the Colonial Army, and that's why Quebec is part of Canada...look it up).

And Franklin, looking at this scary stuff, declined to inoculate his son. Who then, because life isn't fair, died of smallpox.

He wrote about it in his Autobiography 60 years later:

“In 1736 I lost one of my sons, a fine boy of four years old, by the smallpox…I long regretted bitterly, and still regret that I had not given it to him by inoculation. This I mention for the sake of parents who omit that operation...

...on the supposition that they should never forgive themselves if a child died under it; my example showing that the regret may be the same either way, and that, therefore, the safer should be chosen.”-The Autobiography of Benjamin Franklin (1793).

bye for now.