In the 1990s, a British scientist, Jennifer Luke, discovered that fluoride accumulates to strikingly high levels in the pineal gland. The pineal gland is located between the two hemispheres of the brain and is responsible for the synthesis and secretion of the hormone melatonin.
Melatonin maintains the body’s circadian rhythm (sleep-wake cycle), regulates the onset of puberty in females, and helps protect the body from cell damage caused by free radicals.
While it is not yet known if fluoride accumulation affects pineal gland function, preliminary animal experiments found that fluoride reduced melatonin levels and shortened the time to puberty. (Luke, 1997).
Based on this and other evidence, the National Research Council has stated that “fluoride is likely to cause decreased melatonin production and to have other effects on normal pineal function, which in turn could contribute to a variety of effects in humans” (NRC, 2006, p. 256).
The Pineal Gland Has Highest Levels of Fluoride in Body
As a calcifying tissue that is exposed to a high volume of blood flow, the pineal gland is a major target for fluoride accumulation in humans.”
In fact, the calcified parts of the pineal gland (hydroxyapatite crystals) contain the highest fluoride concentrations in the human body (up to 21,000 ppm F), higher than either bone or teeth.
Although the soft tissue of the pineal does not accumulate fluoride to the same extent as the calcified part, it does contain higher levels of fluoride than found than in other types of soft tissue in the body — with concentrations (~300 ppm F)
The impacts of these fluoried concentrations in the pineal aren't yet fully understood,studies have found that calcified deposits in the pineal are associated with decreased numbers of functioning pinealocytes and reduced melatonin production/impairments in the sleep-wake cycle
Fluoride and Earlier Puberty in Girls
In the United States, children are reaching the age of puberty at earlier ages than in the past — a trend that carries health consequences, including a heightened risk for breast cancer.
Fluoride, via its effect on the pineal, could be a contributing cause to this trend. In animal studies, for example, fluoride exposure has been found to cause a decrease in the amount of circulating melatonin and lead to an accelerated sexual maturation in females. (Luke 1997).
Epidemiological studies of human populations drinking fluoridated water- in 1st published fluoridation safety experiment, Newburgh, NY, the authors found that girls living in a fluoridated community reached puberty FIVE months earlier than girls living in a non-fluoridated comm.
(Schlesinger 1956) Later, in 1983, Farkas reported that post-menarcheal girls were “present at younger ages in the higher fluoride town than in the low-fluoride town, although the reported median ages were the same.
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