Read on Twitter
I'm leaning toward joining team "one shot is enough". If you look at the Moderna vaccine, from day 13 or so, to day 27 (2nd dose should be on day 28), there was not a single infection in the vaccine group vs. over 10 in the control. https://twitter.com/EricTopol/status/1351696238874296326
For Pfizer, it looks like there were two infections in the treatment group around days 13 & 14. But, then only 1-2 more infections over the next 10 days, vs. 15-20 in the control.
How to explain away those infections at days 13 & 14? Well, it could be that people were merely tested a bit later, but actually got sick on day 9 or 10. Or maybe they were asymptomatic for a few days after infection, as is common with Covid.
Clearly, there is an issue with vaccine manufacturing and distribution. In the US, total reported distribution has been stuck at 31 million for days. https://www.bloomberg.com/graphics/covid-vaccine-tracker-global-distribution/
Side effects appear more severe for the 2nd dose, while it doesn't appear to actually help matters much. Thus, given the vaccine shortage, we really should strongly look in to waiting or even foregoing the 2nd dose.
Here's a nice thread courtesy @ATabarrok w/ arguments on "First doses First", and this guy didn't even have the Moderna data, which is clearer than for Pfizer. https://twitter.com/ATabarrok/status/1345013648968867840
