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Attn #SciTwitter. I am excited to FINALLY share my new #myelin paper with @Renpeps, @RenaudJolivet and @LabGlial published today in @CellReports! 
https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31630-2
So what is so exciting? I'll summarize
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https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31630-2
So what is so exciting? I'll summarize
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We wanted to know whether mature myelinating #oligodendrocytes could respond to physiological brain activity. So we used low-intensity repetitive transcranial magnetic stimulation (Li-rTMS) to stimulate the motor cortex of adult mice... 2/7
and spatial #learning in the radial arm maze to stimulate the hippocampal-cortical circuit. 3/7
We found that Li-rTMS or spatial learning did not change the gross myelinating morphology of pre-existing #oligodendrocytes but that Li-rTMS shortened nodes of Ranvier in the motor ctx and corpus callosum, while learning lengthened nodes in the fimbria 4/7
These changes in node size occurred independent of oligodendrogenesis and occurred in nodes flanked by pre-existing internodes. 
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Using TEM we show that the changes in node length corresponded with an increase (Li-rTMS) or decrease (learning) in the periaxonal space between the #axon and #myelin internode. 
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Using computational modelling and electrophysiology, we show that these adaptive changes in node length and periaxonal space width worked synergistically to speed up (learning) or slow down (Li-rTMS) conduction velocity along myelinated axon tracts! 7/7
