1/ UK Pandemic Response is harmful to UK immune health & infection resilience: a thread

10 mths of PH messaging:

HOW TO STAY SAFE:
Hands Face Space
Isolate
Avoid people (vectors)
Don't share air
Masks
Social media not F2F
Indoors (Stay the F*** Home)
Be vigilant
Be afraid
2/ Lockdowns, school closures, outdoor sports/gym bans, fear & shame-based PH messages:

Less exercise
Unhealthy eating, wt gain, obesity
Altered gut microbiome
Poor sleep
Stress, anxiety
Social media overuse
Alcohol drugs
Less social interaction

= Adverse impact on IMMUNITY
3/ Worse popn immune health= Worse outcomes from all future viral & bacterial infections not limited to Covid-19

Those who already have a reduced Healthy Life Expectancy most affected

Vaccines will not reverse these impacts.

Vaccines work less well in obese & impaired immunity
4/ EXERCISE IMPROVES IMMUNITY. FRAILTY WORSENS OUTCOMES

Regular bouts of <45min mod intensity exercise is beneficial for immune defence, esp older adults & chronic disease
Reduced exercise = WORSE IMMUNITY
Deconditioning in elderly leads to frailty = worse outcome from C19
5/ OBESITY IS INCREASING in LOCKDOWN.
Increased unhealthy eating habits, weight gain, obesity, diabetes = WORSE IMMUNITY

95% of our local hospitalised Covid patients now obese.

https://covid.joinzoe.com/post/lockdown-weight-gain
6/ OBESITY impairs immunity and WORSENS OUTCOMES

BMI >40 was the second strongest predictor of hospitalisation, after age

For each 1 unit increase in BMI = 12% increase risk of severe C19
7/ STRESS in CHILDHOOD is a risk factor for OBESITY in childhood and adulthood - this has significant long term adverse health consequences

Lockdowns and school closures have increased STRESS in childhood = WORSE IMMUNITY

https://healthyeatingresearch.org/wp-content/uploads/2017/06/her_stress_obesity_5-30.pdf
8/ ALCOHOL:
1 in 20 drinking 5 bottles wine /wk. 38% of people in Furlough drinking more. 39% Relapse of addiction.

Increased alcohol consumption: Negative impact on mental health, sleep, weight & wellbeing = WORSE IMMUNITY https://collateralglobal.org/addiction 
9/ ACTIVITY: Increased social media use/addiction potentially leading to stress, reduced physical activity & negative impact on mental health, sleep, weight and wellbeing = WORSE IMMUNITY
10/ BEING OUTDOORS IMPROVES IMMUNE SYSTEM

Being outdoors and in nature reduces stress, increases Vitamin D production and boosts the immune system, improves mental health & wellbeing

https://www.bbc.com/future/article/20200521-can-staying-inside-weaken-the-immune-system
11/ STRESS and the IMMUNE SYSTEM:

Fear/anxiety (about virus/job security/access to healthcare/home schooling etc)...more time indoors, stress, less exercise, poor sleep, increased drugs alcohol, wt gain, reduced social interaction = WORSE IMMUNITY

https://apps.who.int/iris/bitstream/handle/10665/326983/WH-1994-Mar-Apr-p4-5-eng.pdf
12/ STRESS affects the GUT MICROBIOME:

Stress and anxiety = WORSE IMMUNITY and INCREASED OBESITY
14/ SLEEP LOSS impairs IMMUNE FUNCTION and reduces VACCINE EFFICACY

Restricting sleep to 4 h/night for 6d, followed by sleep for 12 h/night for 7d: > 50% decrease in production of antibodies to flu vacc, compared with subjects who had regular sleep hours

https://www.cdc.gov/niosh/work-hour-training-for-nurses/longhours/mod2/05.html
15/ INTERRUPTIONS to CHILDHOOD VACCINATION PROGRAMMES

Risks resurgence of Measles and worse outcomes from other childhood infections

https://collateralglobal.org/infectious-diseases
16/ A recipe for immune health & resilience:

Eat well low carb/sugar, fresh wholefood, fibre, veg
Intermittent fasts. GI health. Normal BMI
Less alcohol
Regular exercise pref outdoors parks/nature
Sleep well Less socialmedia
(Real) social connection
Reduce stress
Turn off TV
You can follow @HelenMcArdle3.
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