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Really important work going on for the emerging epidemic within the pandemic: methamphetamine use disorder. Brief Study for some efficacy of bupropion + naltrexone (13.6%) v placebo (2.5%). @NEJM. (Brief "why should I care" thread 1/) https://www.nejm.org/doi/full/10.1056/NEJMoa2020214#.YAL2GoQv1So.twitter
A growing body of literature regarding treatment for meth use disorder: mirtazapine also with efficacy in decreasing meth use. RR of mirtaz vs placebo in for meth pos urine 0.67. (2/)
https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2757018 in @JAMA_current
https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2757018 in @JAMA_current
Why care? Methamphetamine use has increased in recent years. Between 2015-2018, past year meth use was reported by approx 1.6 million Americans (3/) https://www.cdc.gov/mmwr/volumes/69/wr/mm6912a1.htm
Meth is problematic for a number of reasons, but it is often co-administered with opioids, increases a persons risk of overdose, HIV, HCV, & bacterial infections. In fact, meth may be the biggest risk factor for HIV among gay men in the U.S (4/) https://www.aidsmap.com/news/sep-2020/crystal-meth-single-biggest-risk-factor-hiv-seroconversion-among-gay-men-us-study
This is leading to increased morbidity, mortality, and costs across the country. It is necessary that @NIDAnews continue to invest in studies of treatments (including stimulant agonists) & treatment DELIVERY; and that @CDCgov work to implement programs. (5/)
cc: @CarlosdelRio7 @SandySpringerMD @NIAIDNews @DrSarahWakeman @LarochelleMarc @BenjaminLinas @RWalensky @alondra @gregggonsalves @chngin_the_wrld
Important that others in the @JoeBiden and @KamalaHarris administration know how crucial this is. cc: @vivek_murthy @IngridKatzMD @drlouiseivers @RonaldKlain @eric_lander
