Zendaya would actually be a better fit for Desire because though young, she gives off Daddy energy. https://twitter.com/GregAndElysee/status/1350220582177148928
Another good Destruction: Chris Evans. (I'm just throwing out actors I like even though they might be too famous for this. Also, I think even if you go with blind casting? Destruction should always, always be a white dude.)
Despair: Mary J. Blige. I know, I know. She looks nothing like the character, but I'm telling you she would KILL THIS.
Despair: Viola Davis. (Now I'm not saying Despair has to be a black actress, but I am saying that the actresses who would give you the best performances are black women.)
Delirium: Tom Holland. (I really don't think Delirium has to present as female. Holland would work. I swear.)
Another one for the Destiny file? John Cho. His default face always looks like he's respectfully allowing someone who only knows a fraction of what he does the chance to speak. Even though they're gonna say something stupid. You need that for the character.
Okay, I'm done. If they cast Sandman with only a whole bunch of white people everyone feel free to retweet this thread for effective dragging.